Recent advances in topical carriers of anti-fungal agents

Fungal skin infections are the most common global issue for skin health. Fungal infections are often treated by topical or systemic anti-fungal therapy. Topical fungal therapy is usually preferred because of their targeted therapy and fewer side effects. Advanced topical carriers because of their di...

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Bibliographic Details
Published in:Heliyon 2020-08, Vol.6 (8), p.e04663-e04663, Article e04663
Main Authors: Garg, Abhinava, Sharma, Ganti S., Goyal, Amit K., Ghosh, Goutam, Si, Sudam Chandra, Rath, Goutam
Format: Article
Language:English
Subjects:
Infectious disease
Liposomes
Materials application
Materials science
Microbiology
Microneedle
Microsponge gel
Nanogel
Nanomaterials
Niosomes
Pharmaceutical science
Solid-lipid nanoparticles
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Summary:Fungal skin infections are the most common global issue for skin health. Fungal infections are often treated by topical or systemic anti-fungal therapy. Topical fungal therapy is usually preferred because of their targeted therapy and fewer side effects. Advanced topical carriers because of their distinct structural and functional features, overcome biopharmaceutical challenges associated with conventional drug delivery systems like poor retention and low bioavailability. Literature evidence indicated topical nanocarriers loaded with anti-fungal agents display superior therapeutic response with minimum toxicity. Nanocarriers often used for topical anti-fungal medication includes Solid-Lipid nanoparticles, Microemulsions, Liposomes, Niosomes, Microsponge, Nanogel, Nanoemulsion, Micelles etc. This review summarizes recent advances in novel strategies employed in topical carriers to improve the therapeutic performance of anti-fungal drugs. Solid-lipid nanoparticles; Liposomes; Niosomes; Microneedle; Microsponge gel; Nanogel; Materials science; Nanomaterials; Materials application; Microbiology; Infectious disease; Pharmaceutical science
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2020.e04663