The short-term effect of vitamin D supplementation on the response to muscle and liver damages indices by exhaustive aerobic exercise in untrained men: a quasi-experimental study

• Published in: BMC sports science, medicine & rehabilitation medicine & rehabilitation, 2022-01, Vol.14 (1), p.7-7, Article 7
• Main Authors: Mastali, Vahid Parvizi, Hoseini, Rastegar, Azizi, Mohammad
• Format: Article
• Language: English
• Subjects: Aerobics; Alfacalcidol; Analysis; Antioxidants; Body mass index; Calcifediol; Creatine; Creatine kinase; Dietary supplements; Enzymes; Exercise; Exhaustive aerobic exercise; Lactose; Liver; Liver diseases; Muscle and liver damage indices; Musculoskeletal system; Neuromuscular diseases; Overweight; Pharmaceutical industry; Phosphatases; Physical fitness; Quasi-experimental methods; Questionnaires; Vitamin D; Vitamin deficiency
• ISSN: 2052-1847; 2052-1847
• DOI: 10.1186/s13102-022-00398-1

Exercise-induced muscle damage typically caused by unaccustomed exercise results in pain, soreness, inflammation, and muscle and liver damages. Antioxidant supplementation might be a useful approach to reduce myocytes and hepatocytes damages. Therefore, the present study was conducted to investigate the effect of short-term vitamin D (Vit D) supplementation on the response to muscle and liver damages indices by Exhaustive Aerobic Exercise (EAE) in untrained men. In this clinical trial, 24 untrained men were randomly divided into experimental (Exp; n = 12) and control (C; n = 12) groups. Exp received 2000 IU of Vit D daily for six weeks (42 days), while C daily received a lactose placebo with the same color, shape, and warmth percentage. Two bouts of EAE were performed on a treadmill before and after six weeks of supplementation. Anthropometric characteristics (Bodyweight (BW), height, Body Fat Percentage (BFP), Body Mass Index (BMI), waist to hip ratio (WHR)) were measured at the Pre 1 and Pre 2. Blood samples were taken to measure the Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), and Vit D levels at four stages: Pre 1 (before the first EE session), Post 1 (after the first EE session), Pre 2 (before the second EE session), and Post 2 (after the second EE session). The data were analyzed using repeated-measures ANOVA, Bonferroni's post hoc test, independent t test, and dependent t-test at the significant level of P