Effect of shape deprivation on retinal thickness in myopic mice using an OCT method

The purpose of this study was to study in retina thickness changes in myopic mice using optical coherence tomography (OCT). There were 18 mice in the form-deprivation myopia (FDM) group，in which the left eye was not treated as a control;18 untreated mice served as a normal control group. The diopter...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-04, Vol.17, p.1156990-1156990
Main Authors: Duan, Ming-Ming, Liu, Hui, Zhong, Yu-Lin
Format: Article
Language:English
Subjects:
Eye
form-deprivation myopia
Hypotheses
Laboratory animals
Medical research
Myopia
myopia mice
Neuroscience
Normal distribution
optical coherence tomography
Optics
Retina
retina thickness
Tomography
Variance analysis
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Summary:The purpose of this study was to study in retina thickness changes in myopic mice using optical coherence tomography (OCT). There were 18 mice in the form-deprivation myopia (FDM) group，in which the left eye was not treated as a control;18 untreated mice served as a normal control group. The diopter of all mice was measured 21 days after birth (P21), before form deprivation. After 4 weeks of form deprivation (P49), the refraction, fundus, and retinal sublayer thickness of all mice were measured. After 4 weeks of form deprivation, the refractive power of the right eye in the FDM group was significantly higher than that in the left eye (
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1156990