Highest Obesity Category Associated With Largest Decrease in N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Heart Failure With Preserved Ejection Fraction

Background Heart failure with preserved ejection fraction (HFpEF) constitutes half of hospitalized heart failure cases and is commonly associated with obesity. The role of natriuretic peptide levels in hospitalized obese patients with HFpEF, however, is not well defined. We sought to evaluate change...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-08, Vol.9 (15), p.e015738-e015738
Main Authors: Vaishnav, Joban, Chasler, Jessica E, Lee, Yizhen J, Ndumele, Chiadi E, Hu, Jiun-Ruey, Schulman, Steven P, Russell, Stuart D, Sharma, Kavita
Format: Article
Language:English
Subjects:
Aged
diuresis
Heart Failure - blood
Heart Failure - physiopathology
heart failure with preserved ejection fraction
Hospitalization
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
natriuretic peptides
NT‐proBNP
obesity
Obesity - blood
Obesity - physiopathology
Original Research
Peptide Fragments - blood
Stroke Volume
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Summary:Background Heart failure with preserved ejection fraction (HFpEF) constitutes half of hospitalized heart failure cases and is commonly associated with obesity. The role of natriuretic peptide levels in hospitalized obese patients with HFpEF, however, is not well defined. We sought to evaluate change in NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels by obesity category and related clinical outcomes in patients with HFpEF hospitalized for acute heart failure. Methods and Results A total of 89 patients with HFpEF hospitalized with acute decompensated heart failure were stratified into 3 obesity categories: nonobese (body mass index [BMI]
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.015738