Symptoms of depression change with olfactory function

Olfactory loss is associated with symptoms of depression. The present study, conducted on a large cohort of mostly dysosmic patients, aimed to investigate whether improvement in olfactory performance would correspond with a decrease in depression severity. In 171 participants (157 dysosmic), we asse...

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Bibliographic Details
Published in:Scientific reports 2022-04, Vol.12 (1), p.5656-5656, Article 5656
Main Authors: Sabiniewicz, Agnieszka, Hoffmann, Leonie, Haehner, Antje, Hummel, Thomas
Format: Article
Language:English
Subjects:
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Bayes Theorem
Bayesian analysis
Depression
Humanities and Social Sciences
Humans
Mental depression
multidisciplinary
Odor thresholds
Odorants
Odors
Olfaction
Olfaction Disorders
Olfactory discrimination
Olfactory thresholds
Science
Science (multidisciplinary)
Smell
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Summary:Olfactory loss is associated with symptoms of depression. The present study, conducted on a large cohort of mostly dysosmic patients, aimed to investigate whether improvement in olfactory performance would correspond with a decrease in depression severity. In 171 participants (157 dysosmic), we assessed olfactory function and severity of depression before and after an average interval of 11 months, with many patients showing improvement in olfactory function. Separate analyses were conducted for (a) the whole group of patients and (b) the group of dysosmic patients using both classic and Bayesian approaches. For odor identification, Student t test demonstrated that the whole sample improved consistently, especially within the group of dysosmic patients. The dysosmic group also improved in odor threshold and overall olfactory function. Pearson correlation showed that an increase in olfactory function was associated with a decrease in depression severity, particularly in dysosmic patients. To conclude, the present results indicate that symptoms of depression change with olfactory function in general and odor identification in particular.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-09650-7