Gestational Hypoxia and Programing of Lung Metabolism

Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the newborn and other sequela, however, the mechanisms associated with the disease remain poorly understood. This review highlights disruption of metabolism by antenatal high altitude hypoxia and the impact this has...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in physiology 2019-11, Vol.10, p.1453-1453
Main Authors: Rood, Kristiana, Lopez, Vanessa, La Frano, Michael R, Fiehn, Oliver, Zhang, Lubo, Blood, Arlin B, Wilson, Sean M
Format: Article
Language:English
Subjects:
fetus
hypoxia
metabolomics
Physiology
pulmonary artery
sheep
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the newborn and other sequela, however, the mechanisms associated with the disease remain poorly understood. This review highlights disruption of metabolism by antenatal high altitude hypoxia and the impact this has on pulmonary hypertension in the newborn with discussion of model organisms and human populations. There is particular emphasis on modifications in glucose and lipid metabolism along with alterations in mitochondrial function. Additional focus is placed on increases in oxidative stress and the progression of pulmonary vascular disease in the newborn and on the need for further exploration using a combination of contemporary and classical approaches.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2019.01453