LATENT TUBERCULOSIS IN PATIENTS WITH CROHN'S DISEASE IN A UNIVERSITY HOSPITAL IN NORTHEASTERN BRAZIL: A RETROSPECTIVE STUDY

• Published in: Arquivos de gastroenterologia 2024, Vol.61, p.e23105
• Main Authors: Melo, Ivone Venâncio de, Santos, Mariana Oliveira, Sousa, Karinna Alves Amorim de, Abi-Chacra, Erika Araújo, Araújo, Telma Maria Evangelista de, Lima, Murilo Moura, Parente, José Miguel Luz, Campelo, Viriato
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antitubercular Agents - therapeutic use; Brazil - epidemiology; Crohn Disease - complications; Crohn’s disease; Cross-Sectional Studies; epidemiology; Female; GASTROENTEROLOGY & HEPATOLOGY; Hospitals, University - statistics & numerical data; Humans; Isoniazid - therapeutic use; Latent tuberculosis; Latent Tuberculosis - complications; Latent Tuberculosis - diagnosis; Latent Tuberculosis - epidemiology; Male; Middle Aged; Retrospective Studies; Rifampin - therapeutic use; tuberculin test; Young Adult
• ISSN: 0004-2803; 1678-4219; 1678-4219
• DOI: 10.1590/s0004-2803.24612023-105

Among chronic condition problems, tuberculosis still represents a serious public health problem globally. To investigate latent tuberculosis infection in patients with Crohn's disease. Retrospective, descriptive cross-sectional study of quantitative analysis. The research was conducted on diagnosed cases of Crohn's disease at the University Hospital located in a city in Northeastern Brazil. All cases of patients with Crohn's disease undergoing isoniazid or rifampicin therapy for latent tuberculosis (LTBI) were included in the study. The data obtained were subsequently subjected to statistical analysis using the Statistical Package for the Social Sciences (SPSS) program. We analyzed 235 medical records, and it was observed that 56% were male, with a mean age of 42.7. Among these, 54% declared themselves as brown, 31% had completed high school, and 47% were residents of the city of Teresina. Regarding the clinical and epidemiological characteristics of the studied patients classified as having ILTB, 34% of the medical records were diagnosed by tuberculin test, 48.51% were investigated by x-ray examination, and the recent location affected the colon with 27%. Overall, the health profile of the participants in this study aligns with findings previously established in the literature, particularly studies conducted in other Brazilian states, as well as in other developing countries.