Younger age of onset and uveitis associated with HLA-B27 and delayed diagnosis in Thai patients with axial spondyloarthritis

• Published in: Scientific reports 2021-06, Vol.11 (1), p.13536-13536, Article 13536
• Main Authors: Limsakul, Naphruet, Chiowchanwisawakit, Praveena, Permpikul, Parichart, Thanaketpaisarn, Yubolrat
• Format: Article
• Language: English
• Subjects: 631/208; 631/208/2489; 692/4023; Age; Arthritis; C-reactive protein; Diagnosis; Humanities and Social Sciences; Inflammatory diseases; multidisciplinary; Multiple regression analysis; Patients; Protein structure; Psoriasis; Regression analysis; Rheumatic diseases; Science; Science (multidisciplinary); Skin diseases; Uveitis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-93001-5

To identify characteristics associated with HLA-B27, and to identify factors associated with delayed diagnosis in Thai patients with axial spondyloarthritis (axSpA). This cross-sectional study included Thai patients were diagnosed with axSpA by a rheumatologist at Siriraj Hospital. Clinical data were collected. Regression analyses were employed to identify factors associated with study outcomes. Of total 177 patients, 127 (72%) were positive HLA-B27. Uveitis [Odds ratio (OR) 4.0], age at onset of the first musculoskeletal symptom of ≤ 28 years [OR 3.5], female [OR 0.4], and psoriasis [OR 0.4] were significantly associated with HLA-B27 in multiple regression analysis. Those with positive HLA-B27 had less spinal flexibility. Elevated C-reactive protein ( p  = 0.012) was associated with shorter delay in diagnosis, while uveitis ( p