Systems bioengineering approaches for developmental toxicology

Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the complex interactions between developing organis...

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Bibliographic Details
Published in:Computational and structural biotechnology journal 2023-01, Vol.21, p.3272-3279
Main Authors: Soares, Beatriz Xavier, Miranda, Cláudia C., Fernandes, Tiago G.
Format: Article
Language:English
Subjects:
Developmental toxicology
High-throughput screening
Human pluripotent stem cells
Mathematical modeling
Mini-Review
Systems bioengineering
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Summary:Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the complex interactions between developing organisms, the environment, and toxic agents. This approach would result in a holistic understanding of the effects of toxic agents on organisms, by considering the interactions between different biological systems and the impacts of toxicants on those interactions. It would be useful in identifying key biological pathways and mechanisms affected by toxic agents, as well as in the development of predictive models to assess potential risks of exposure to toxicants during development. In this review, we discuss the relevance of systems bioengineering to the field of developmental toxicity and provide up-to-date examples that illustrate the use of engineering principles for this application.
ISSN:2001-0370
2001-0370
DOI:10.1016/j.csbj.2023.06.005