Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The...

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Bibliographic Details
Published in:Pathogens (Basel) 2021-11, Vol.10 (11), p.1506
Main Authors: Chen, Shaorong, Zhang, Dongmei, Roberts, Alexandria-Jade, Lu, Hsueh-Chung, Cannon, Carolyn L., Qin, Qing-Ming, de Figueiredo, Paul
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial infections
bacterial pathogens
Communication
Complement
Complement system
Cytotoxicity
Drug resistance
Elastase
host complement system
host immune system
Hypotheses
Immune system
Leukocytes (neutrophilic)
multidrug resistant bacteria
Pathogens
Protease
protease neutrophil elastase
Proteinase
Pseudomonas aeruginosa
Vaccines
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Summary:Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10111506