Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and...

Full description

Saved in:
Bibliographic Details
Published in:The world journal of men's health 2022-07, Vol.40 (3), p.347-360
Main Authors: Agarwal, Ashok, Sharma, Rakesh, Gupta, Sajal, Finelli, Renata, Parekh, Neel, Panner Selvam, Manesh Kumar, Henkel, Ralf, Durairajanayagam, Damayanthi, Pompeu, Camila, Madani, Sarah, Belo, Andrea, Singh, Neha, Covarrubias, Simryn, Darbandi, Sara, Sadeghi, Raha, Darbandi, Mahsa, Vogiatzi, Paraskevi, Boitrelle, Florence, Simopoulou, Mara, Saleh, Ramadan, Arafa, Mohamed, Majzoub, Ahmad, Kandil, Hussein, Zini, Armand, Ko, Edmund, Alvarez, Juan G, Martinez, Marlon, Ramsay, Jonathan, Jindal, Sunil, Busetto, Gian Maria, Sallam, Hassan, Maldonado, Israel, Anagnostopoulou, Christina, Alves, Marco G, Sengupta, Pallav, Gilany, Kambiz, Evenson, Donald P, Lewis, Sheena E M, Gosalvez, Jaime, Ambar, Rafael F, Shah, Rupin
Format: Article
Language:English
Subjects:
abnormality
In vitro fertilization
Infertility
Laboratories
Life Sciences
Morphology
Motility
Quality control
Reproductive Biology
Reproductive technologies
Review
Sperm
stain
Stains & staining
teratozoospermia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23
cites cdi_FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23
container_end_page 360
container_issue 3
container_start_page 347
container_title The world journal of men's health
container_volume 40
creator Agarwal, Ashok
Sharma, Rakesh
Gupta, Sajal
Finelli, Renata
Parekh, Neel
Panner Selvam, Manesh Kumar
Henkel, Ralf
Durairajanayagam, Damayanthi
Pompeu, Camila
Madani, Sarah
Belo, Andrea
Singh, Neha
Covarrubias, Simryn
Darbandi, Sara
Sadeghi, Raha
Darbandi, Mahsa
Vogiatzi, Paraskevi
Boitrelle, Florence
Simopoulou, Mara
Saleh, Ramadan
Arafa, Mohamed
Majzoub, Ahmad
Kandil, Hussein
Zini, Armand
Ko, Edmund
Alvarez, Juan G
Martinez, Marlon
Ramsay, Jonathan
Jindal, Sunil
Busetto, Gian Maria
Sallam, Hassan
Maldonado, Israel
Anagnostopoulou, Christina
Alves, Marco G
Sengupta, Pallav
Gilany, Kambiz
Evenson, Donald P
Lewis, Sheena E M
Gosalvez, Jaime
Ambar, Rafael F
Shah, Rupin
description Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.
doi_str_mv 10.5534/wjmh.210054
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_93d331e2c22445abb5941164b4b1acf7</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_93d331e2c22445abb5941164b4b1acf7</doaj_id><sourcerecordid>2814337646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23</originalsourceid><addsrcrecordid>eNpdkl9rFDEUxQdRbKl98l0CPondmn8zSXwQlqW1Cyuirc8hk8nsZJlJtkmmsn4WP6wZpy3WvNxw7zm_kMspitcInpcloR9-7obuHCMIS_qsOMaYswWtBHz-cMeQHxWnMe5gPhxCBtHL4ohQVImKs-Pi9_XehAF88WHf-d5vD2AZo4lxMC4B60DqDLgICvgWrF0KSh-S3_cqDlaD2bp2O6OT9e4j-G56q-re5Esc-xRzvR1tMODS6zEC78B1Uq5RobG_1GQ5A99G1dt0ACuf6b4_A3kOboKyzrrtq-JFq_poTu_rSfHj8uJmdbXYfP28Xi03C11CkRaINbTlQmuuSU0rXla8VZRqQ1oGcW1IpQSCiArBMC0rWtNW6EZgymA2akxOivXMbbzayX2wgwoH6ZWVfxs-bKUKyereSEEaQpDBGmNKS1XXpaAITcwaKd2yzPo0s_ZjPZhGm2lr_RPo04mzndz6OylwSZjgGfBuBnT_2a6WGzn1IMGMC0jvUNa-vX8s-NvRxCR3fgwu70pijighrKJVVr2fVTr4GINpH7EIyilFckqRnFOU1W_-_cCj9iEz5A9DoMSU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2814337646</pqid></control><display><type>article</type><title>Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Agarwal, Ashok ; Sharma, Rakesh ; Gupta, Sajal ; Finelli, Renata ; Parekh, Neel ; Panner Selvam, Manesh Kumar ; Henkel, Ralf ; Durairajanayagam, Damayanthi ; Pompeu, Camila ; Madani, Sarah ; Belo, Andrea ; Singh, Neha ; Covarrubias, Simryn ; Darbandi, Sara ; Sadeghi, Raha ; Darbandi, Mahsa ; Vogiatzi, Paraskevi ; Boitrelle, Florence ; Simopoulou, Mara ; Saleh, Ramadan ; Arafa, Mohamed ; Majzoub, Ahmad ; Kandil, Hussein ; Zini, Armand ; Ko, Edmund ; Alvarez, Juan G ; Martinez, Marlon ; Ramsay, Jonathan ; Jindal, Sunil ; Busetto, Gian Maria ; Sallam, Hassan ; Maldonado, Israel ; Anagnostopoulou, Christina ; Alves, Marco G ; Sengupta, Pallav ; Gilany, Kambiz ; Evenson, Donald P ; Lewis, Sheena E M ; Gosalvez, Jaime ; Ambar, Rafael F ; Shah, Rupin</creator><creatorcontrib>Agarwal, Ashok ; Sharma, Rakesh ; Gupta, Sajal ; Finelli, Renata ; Parekh, Neel ; Panner Selvam, Manesh Kumar ; Henkel, Ralf ; Durairajanayagam, Damayanthi ; Pompeu, Camila ; Madani, Sarah ; Belo, Andrea ; Singh, Neha ; Covarrubias, Simryn ; Darbandi, Sara ; Sadeghi, Raha ; Darbandi, Mahsa ; Vogiatzi, Paraskevi ; Boitrelle, Florence ; Simopoulou, Mara ; Saleh, Ramadan ; Arafa, Mohamed ; Majzoub, Ahmad ; Kandil, Hussein ; Zini, Armand ; Ko, Edmund ; Alvarez, Juan G ; Martinez, Marlon ; Ramsay, Jonathan ; Jindal, Sunil ; Busetto, Gian Maria ; Sallam, Hassan ; Maldonado, Israel ; Anagnostopoulou, Christina ; Alves, Marco G ; Sengupta, Pallav ; Gilany, Kambiz ; Evenson, Donald P ; Lewis, Sheena E M ; Gosalvez, Jaime ; Ambar, Rafael F ; Shah, Rupin</creatorcontrib><description>Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.</description><identifier>ISSN: 2287-4208</identifier><identifier>EISSN: 2287-4690</identifier><identifier>DOI: 10.5534/wjmh.210054</identifier><identifier>PMID: 34169687</identifier><language>eng</language><publisher>Korea (South): Korean Society for Sexual Medicine and Andrology</publisher><subject>abnormality ; In vitro fertilization ; Infertility ; Laboratories ; Life Sciences ; Morphology ; Motility ; Quality control ; Reproductive Biology ; Reproductive technologies ; Review ; Sperm ; stain ; Stains &amp; staining ; teratozoospermia</subject><ispartof>The world journal of men's health, 2022-07, Vol.40 (3), p.347-360</ispartof><rights>Copyright © 2022 Korean Society for Sexual Medicine and Andrology.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution - NonCommercial</rights><rights>Copyright © 2022 Korean Society for Sexual Medicine and Andrology 2022 Korean Society for Sexual Medicine and Andrology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23</citedby><cites>FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23</cites><orcidid>0000-0001-9971-1619 ; 0000-0002-5549-3274 ; 0000-0002-6311-8706 ; 0000-0002-4851-9579 ; 0000-0001-6487-9681 ; 0000-0002-2403-7698 ; 0000-0002-5472-400X ; 0000-0001-9049-0215 ; 0000-0003-0107-8857 ; 0000-0002-7291-0316 ; 0000-0002-7465-3616 ; 0000-0002-5926-6407 ; 0000-0001-7423-6241 ; 0000-0002-9792-7587 ; 0000-0002-8088-8710 ; 0000-0002-1928-5048 ; 0000-0003-0999-6484 ; 0000-0002-7151-0273 ; 0000-0002-3496-2895 ; 0000-0002-1000-9100 ; 0000-0002-9664-6978 ; 0000-0002-1868-6712 ; 0000-0003-0503-3533 ; 0000-0003-2765-6176 ; 0000-0002-9085-0097 ; 0000-0002-6218-9254 ; 0000-0001-7635-783X ; 0000-0003-1308-6280 ; 0000-0002-7868-5949 ; 0000-0003-1128-2982 ; 0000-0002-2243-9319 ; 0000-0002-5322-0141 ; 0000-0002-1191-8154 ; 0000-0003-0585-1026 ; 0000-0002-0887-0129 ; 0000-0003-3624-4261 ; 0000-0002-2194-5578 ; 0000-0002-7111-9477 ; 0000-0002-3620-0819 ; 0000-0002-9120-2278 ; 0000-0001-5665-1572</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2814337646/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2814337646?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,724,777,781,789,882,25734,27903,27905,27906,36993,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34169687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03278904$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, Ashok</creatorcontrib><creatorcontrib>Sharma, Rakesh</creatorcontrib><creatorcontrib>Gupta, Sajal</creatorcontrib><creatorcontrib>Finelli, Renata</creatorcontrib><creatorcontrib>Parekh, Neel</creatorcontrib><creatorcontrib>Panner Selvam, Manesh Kumar</creatorcontrib><creatorcontrib>Henkel, Ralf</creatorcontrib><creatorcontrib>Durairajanayagam, Damayanthi</creatorcontrib><creatorcontrib>Pompeu, Camila</creatorcontrib><creatorcontrib>Madani, Sarah</creatorcontrib><creatorcontrib>Belo, Andrea</creatorcontrib><creatorcontrib>Singh, Neha</creatorcontrib><creatorcontrib>Covarrubias, Simryn</creatorcontrib><creatorcontrib>Darbandi, Sara</creatorcontrib><creatorcontrib>Sadeghi, Raha</creatorcontrib><creatorcontrib>Darbandi, Mahsa</creatorcontrib><creatorcontrib>Vogiatzi, Paraskevi</creatorcontrib><creatorcontrib>Boitrelle, Florence</creatorcontrib><creatorcontrib>Simopoulou, Mara</creatorcontrib><creatorcontrib>Saleh, Ramadan</creatorcontrib><creatorcontrib>Arafa, Mohamed</creatorcontrib><creatorcontrib>Majzoub, Ahmad</creatorcontrib><creatorcontrib>Kandil, Hussein</creatorcontrib><creatorcontrib>Zini, Armand</creatorcontrib><creatorcontrib>Ko, Edmund</creatorcontrib><creatorcontrib>Alvarez, Juan G</creatorcontrib><creatorcontrib>Martinez, Marlon</creatorcontrib><creatorcontrib>Ramsay, Jonathan</creatorcontrib><creatorcontrib>Jindal, Sunil</creatorcontrib><creatorcontrib>Busetto, Gian Maria</creatorcontrib><creatorcontrib>Sallam, Hassan</creatorcontrib><creatorcontrib>Maldonado, Israel</creatorcontrib><creatorcontrib>Anagnostopoulou, Christina</creatorcontrib><creatorcontrib>Alves, Marco G</creatorcontrib><creatorcontrib>Sengupta, Pallav</creatorcontrib><creatorcontrib>Gilany, Kambiz</creatorcontrib><creatorcontrib>Evenson, Donald P</creatorcontrib><creatorcontrib>Lewis, Sheena E M</creatorcontrib><creatorcontrib>Gosalvez, Jaime</creatorcontrib><creatorcontrib>Ambar, Rafael F</creatorcontrib><creatorcontrib>Shah, Rupin</creatorcontrib><title>Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training</title><title>The world journal of men's health</title><addtitle>World J Mens Health</addtitle><description>Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.</description><subject>abnormality</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Motility</subject><subject>Quality control</subject><subject>Reproductive Biology</subject><subject>Reproductive technologies</subject><subject>Review</subject><subject>Sperm</subject><subject>stain</subject><subject>Stains &amp; staining</subject><subject>teratozoospermia</subject><issn>2287-4208</issn><issn>2287-4690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkl9rFDEUxQdRbKl98l0CPondmn8zSXwQlqW1Cyuirc8hk8nsZJlJtkmmsn4WP6wZpy3WvNxw7zm_kMspitcInpcloR9-7obuHCMIS_qsOMaYswWtBHz-cMeQHxWnMe5gPhxCBtHL4ohQVImKs-Pi9_XehAF88WHf-d5vD2AZo4lxMC4B60DqDLgICvgWrF0KSh-S3_cqDlaD2bp2O6OT9e4j-G56q-re5Esc-xRzvR1tMODS6zEC78B1Uq5RobG_1GQ5A99G1dt0ACuf6b4_A3kOboKyzrrtq-JFq_poTu_rSfHj8uJmdbXYfP28Xi03C11CkRaINbTlQmuuSU0rXla8VZRqQ1oGcW1IpQSCiArBMC0rWtNW6EZgymA2akxOivXMbbzayX2wgwoH6ZWVfxs-bKUKyereSEEaQpDBGmNKS1XXpaAITcwaKd2yzPo0s_ZjPZhGm2lr_RPo04mzndz6OylwSZjgGfBuBnT_2a6WGzn1IMGMC0jvUNa-vX8s-NvRxCR3fgwu70pijighrKJVVr2fVTr4GINpH7EIyilFckqRnFOU1W_-_cCj9iEz5A9DoMSU</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Agarwal, Ashok</creator><creator>Sharma, Rakesh</creator><creator>Gupta, Sajal</creator><creator>Finelli, Renata</creator><creator>Parekh, Neel</creator><creator>Panner Selvam, Manesh Kumar</creator><creator>Henkel, Ralf</creator><creator>Durairajanayagam, Damayanthi</creator><creator>Pompeu, Camila</creator><creator>Madani, Sarah</creator><creator>Belo, Andrea</creator><creator>Singh, Neha</creator><creator>Covarrubias, Simryn</creator><creator>Darbandi, Sara</creator><creator>Sadeghi, Raha</creator><creator>Darbandi, Mahsa</creator><creator>Vogiatzi, Paraskevi</creator><creator>Boitrelle, Florence</creator><creator>Simopoulou, Mara</creator><creator>Saleh, Ramadan</creator><creator>Arafa, Mohamed</creator><creator>Majzoub, Ahmad</creator><creator>Kandil, Hussein</creator><creator>Zini, Armand</creator><creator>Ko, Edmund</creator><creator>Alvarez, Juan G</creator><creator>Martinez, Marlon</creator><creator>Ramsay, Jonathan</creator><creator>Jindal, Sunil</creator><creator>Busetto, Gian Maria</creator><creator>Sallam, Hassan</creator><creator>Maldonado, Israel</creator><creator>Anagnostopoulou, Christina</creator><creator>Alves, Marco G</creator><creator>Sengupta, Pallav</creator><creator>Gilany, Kambiz</creator><creator>Evenson, Donald P</creator><creator>Lewis, Sheena E M</creator><creator>Gosalvez, Jaime</creator><creator>Ambar, Rafael F</creator><creator>Shah, Rupin</creator><general>Korean Society for Sexual Medicine and Andrology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7R6</scope><scope>888</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQGEN</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>QXPDG</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9971-1619</orcidid><orcidid>https://orcid.org/0000-0002-5549-3274</orcidid><orcidid>https://orcid.org/0000-0002-6311-8706</orcidid><orcidid>https://orcid.org/0000-0002-4851-9579</orcidid><orcidid>https://orcid.org/0000-0001-6487-9681</orcidid><orcidid>https://orcid.org/0000-0002-2403-7698</orcidid><orcidid>https://orcid.org/0000-0002-5472-400X</orcidid><orcidid>https://orcid.org/0000-0001-9049-0215</orcidid><orcidid>https://orcid.org/0000-0003-0107-8857</orcidid><orcidid>https://orcid.org/0000-0002-7291-0316</orcidid><orcidid>https://orcid.org/0000-0002-7465-3616</orcidid><orcidid>https://orcid.org/0000-0002-5926-6407</orcidid><orcidid>https://orcid.org/0000-0001-7423-6241</orcidid><orcidid>https://orcid.org/0000-0002-9792-7587</orcidid><orcidid>https://orcid.org/0000-0002-8088-8710</orcidid><orcidid>https://orcid.org/0000-0002-1928-5048</orcidid><orcidid>https://orcid.org/0000-0003-0999-6484</orcidid><orcidid>https://orcid.org/0000-0002-7151-0273</orcidid><orcidid>https://orcid.org/0000-0002-3496-2895</orcidid><orcidid>https://orcid.org/0000-0002-1000-9100</orcidid><orcidid>https://orcid.org/0000-0002-9664-6978</orcidid><orcidid>https://orcid.org/0000-0002-1868-6712</orcidid><orcidid>https://orcid.org/0000-0003-0503-3533</orcidid><orcidid>https://orcid.org/0000-0003-2765-6176</orcidid><orcidid>https://orcid.org/0000-0002-9085-0097</orcidid><orcidid>https://orcid.org/0000-0002-6218-9254</orcidid><orcidid>https://orcid.org/0000-0001-7635-783X</orcidid><orcidid>https://orcid.org/0000-0003-1308-6280</orcidid><orcidid>https://orcid.org/0000-0002-7868-5949</orcidid><orcidid>https://orcid.org/0000-0003-1128-2982</orcidid><orcidid>https://orcid.org/0000-0002-2243-9319</orcidid><orcidid>https://orcid.org/0000-0002-5322-0141</orcidid><orcidid>https://orcid.org/0000-0002-1191-8154</orcidid><orcidid>https://orcid.org/0000-0003-0585-1026</orcidid><orcidid>https://orcid.org/0000-0002-0887-0129</orcidid><orcidid>https://orcid.org/0000-0003-3624-4261</orcidid><orcidid>https://orcid.org/0000-0002-2194-5578</orcidid><orcidid>https://orcid.org/0000-0002-7111-9477</orcidid><orcidid>https://orcid.org/0000-0002-3620-0819</orcidid><orcidid>https://orcid.org/0000-0002-9120-2278</orcidid><orcidid>https://orcid.org/0000-0001-5665-1572</orcidid></search><sort><creationdate>20220701</creationdate><title>Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training</title><author>Agarwal, Ashok ; Sharma, Rakesh ; Gupta, Sajal ; Finelli, Renata ; Parekh, Neel ; Panner Selvam, Manesh Kumar ; Henkel, Ralf ; Durairajanayagam, Damayanthi ; Pompeu, Camila ; Madani, Sarah ; Belo, Andrea ; Singh, Neha ; Covarrubias, Simryn ; Darbandi, Sara ; Sadeghi, Raha ; Darbandi, Mahsa ; Vogiatzi, Paraskevi ; Boitrelle, Florence ; Simopoulou, Mara ; Saleh, Ramadan ; Arafa, Mohamed ; Majzoub, Ahmad ; Kandil, Hussein ; Zini, Armand ; Ko, Edmund ; Alvarez, Juan G ; Martinez, Marlon ; Ramsay, Jonathan ; Jindal, Sunil ; Busetto, Gian Maria ; Sallam, Hassan ; Maldonado, Israel ; Anagnostopoulou, Christina ; Alves, Marco G ; Sengupta, Pallav ; Gilany, Kambiz ; Evenson, Donald P ; Lewis, Sheena E M ; Gosalvez, Jaime ; Ambar, Rafael F ; Shah, Rupin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>abnormality</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Morphology</topic><topic>Motility</topic><topic>Quality control</topic><topic>Reproductive Biology</topic><topic>Reproductive technologies</topic><topic>Review</topic><topic>Sperm</topic><topic>stain</topic><topic>Stains &amp; staining</topic><topic>teratozoospermia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, Ashok</creatorcontrib><creatorcontrib>Sharma, Rakesh</creatorcontrib><creatorcontrib>Gupta, Sajal</creatorcontrib><creatorcontrib>Finelli, Renata</creatorcontrib><creatorcontrib>Parekh, Neel</creatorcontrib><creatorcontrib>Panner Selvam, Manesh Kumar</creatorcontrib><creatorcontrib>Henkel, Ralf</creatorcontrib><creatorcontrib>Durairajanayagam, Damayanthi</creatorcontrib><creatorcontrib>Pompeu, Camila</creatorcontrib><creatorcontrib>Madani, Sarah</creatorcontrib><creatorcontrib>Belo, Andrea</creatorcontrib><creatorcontrib>Singh, Neha</creatorcontrib><creatorcontrib>Covarrubias, Simryn</creatorcontrib><creatorcontrib>Darbandi, Sara</creatorcontrib><creatorcontrib>Sadeghi, Raha</creatorcontrib><creatorcontrib>Darbandi, Mahsa</creatorcontrib><creatorcontrib>Vogiatzi, Paraskevi</creatorcontrib><creatorcontrib>Boitrelle, Florence</creatorcontrib><creatorcontrib>Simopoulou, Mara</creatorcontrib><creatorcontrib>Saleh, Ramadan</creatorcontrib><creatorcontrib>Arafa, Mohamed</creatorcontrib><creatorcontrib>Majzoub, Ahmad</creatorcontrib><creatorcontrib>Kandil, Hussein</creatorcontrib><creatorcontrib>Zini, Armand</creatorcontrib><creatorcontrib>Ko, Edmund</creatorcontrib><creatorcontrib>Alvarez, Juan G</creatorcontrib><creatorcontrib>Martinez, Marlon</creatorcontrib><creatorcontrib>Ramsay, Jonathan</creatorcontrib><creatorcontrib>Jindal, Sunil</creatorcontrib><creatorcontrib>Busetto, Gian Maria</creatorcontrib><creatorcontrib>Sallam, Hassan</creatorcontrib><creatorcontrib>Maldonado, Israel</creatorcontrib><creatorcontrib>Anagnostopoulou, Christina</creatorcontrib><creatorcontrib>Alves, Marco G</creatorcontrib><creatorcontrib>Sengupta, Pallav</creatorcontrib><creatorcontrib>Gilany, Kambiz</creatorcontrib><creatorcontrib>Evenson, Donald P</creatorcontrib><creatorcontrib>Lewis, Sheena E M</creatorcontrib><creatorcontrib>Gosalvez, Jaime</creatorcontrib><creatorcontrib>Ambar, Rafael F</creatorcontrib><creatorcontrib>Shah, Rupin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>GenderWatch</collection><collection>GenderWatch (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest Women's &amp; Gender Studies</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Diversity Collection</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>The world journal of men's health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, Ashok</au><au>Sharma, Rakesh</au><au>Gupta, Sajal</au><au>Finelli, Renata</au><au>Parekh, Neel</au><au>Panner Selvam, Manesh Kumar</au><au>Henkel, Ralf</au><au>Durairajanayagam, Damayanthi</au><au>Pompeu, Camila</au><au>Madani, Sarah</au><au>Belo, Andrea</au><au>Singh, Neha</au><au>Covarrubias, Simryn</au><au>Darbandi, Sara</au><au>Sadeghi, Raha</au><au>Darbandi, Mahsa</au><au>Vogiatzi, Paraskevi</au><au>Boitrelle, Florence</au><au>Simopoulou, Mara</au><au>Saleh, Ramadan</au><au>Arafa, Mohamed</au><au>Majzoub, Ahmad</au><au>Kandil, Hussein</au><au>Zini, Armand</au><au>Ko, Edmund</au><au>Alvarez, Juan G</au><au>Martinez, Marlon</au><au>Ramsay, Jonathan</au><au>Jindal, Sunil</au><au>Busetto, Gian Maria</au><au>Sallam, Hassan</au><au>Maldonado, Israel</au><au>Anagnostopoulou, Christina</au><au>Alves, Marco G</au><au>Sengupta, Pallav</au><au>Gilany, Kambiz</au><au>Evenson, Donald P</au><au>Lewis, Sheena E M</au><au>Gosalvez, Jaime</au><au>Ambar, Rafael F</au><au>Shah, Rupin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training</atitle><jtitle>The world journal of men's health</jtitle><addtitle>World J Mens Health</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>40</volume><issue>3</issue><spage>347</spage><epage>360</epage><pages>347-360</pages><issn>2287-4208</issn><eissn>2287-4690</eissn><abstract>Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.</abstract><cop>Korea (South)</cop><pub>Korean Society for Sexual Medicine and Andrology</pub><pmid>34169687</pmid><doi>10.5534/wjmh.210054</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9971-1619</orcidid><orcidid>https://orcid.org/0000-0002-5549-3274</orcidid><orcidid>https://orcid.org/0000-0002-6311-8706</orcidid><orcidid>https://orcid.org/0000-0002-4851-9579</orcidid><orcidid>https://orcid.org/0000-0001-6487-9681</orcidid><orcidid>https://orcid.org/0000-0002-2403-7698</orcidid><orcidid>https://orcid.org/0000-0002-5472-400X</orcidid><orcidid>https://orcid.org/0000-0001-9049-0215</orcidid><orcidid>https://orcid.org/0000-0003-0107-8857</orcidid><orcidid>https://orcid.org/0000-0002-7291-0316</orcidid><orcidid>https://orcid.org/0000-0002-7465-3616</orcidid><orcidid>https://orcid.org/0000-0002-5926-6407</orcidid><orcidid>https://orcid.org/0000-0001-7423-6241</orcidid><orcidid>https://orcid.org/0000-0002-9792-7587</orcidid><orcidid>https://orcid.org/0000-0002-8088-8710</orcidid><orcidid>https://orcid.org/0000-0002-1928-5048</orcidid><orcidid>https://orcid.org/0000-0003-0999-6484</orcidid><orcidid>https://orcid.org/0000-0002-7151-0273</orcidid><orcidid>https://orcid.org/0000-0002-3496-2895</orcidid><orcidid>https://orcid.org/0000-0002-1000-9100</orcidid><orcidid>https://orcid.org/0000-0002-9664-6978</orcidid><orcidid>https://orcid.org/0000-0002-1868-6712</orcidid><orcidid>https://orcid.org/0000-0003-0503-3533</orcidid><orcidid>https://orcid.org/0000-0003-2765-6176</orcidid><orcidid>https://orcid.org/0000-0002-9085-0097</orcidid><orcidid>https://orcid.org/0000-0002-6218-9254</orcidid><orcidid>https://orcid.org/0000-0001-7635-783X</orcidid><orcidid>https://orcid.org/0000-0003-1308-6280</orcidid><orcidid>https://orcid.org/0000-0002-7868-5949</orcidid><orcidid>https://orcid.org/0000-0003-1128-2982</orcidid><orcidid>https://orcid.org/0000-0002-2243-9319</orcidid><orcidid>https://orcid.org/0000-0002-5322-0141</orcidid><orcidid>https://orcid.org/0000-0002-1191-8154</orcidid><orcidid>https://orcid.org/0000-0003-0585-1026</orcidid><orcidid>https://orcid.org/0000-0002-0887-0129</orcidid><orcidid>https://orcid.org/0000-0003-3624-4261</orcidid><orcidid>https://orcid.org/0000-0002-2194-5578</orcidid><orcidid>https://orcid.org/0000-0002-7111-9477</orcidid><orcidid>https://orcid.org/0000-0002-3620-0819</orcidid><orcidid>https://orcid.org/0000-0002-9120-2278</orcidid><orcidid>https://orcid.org/0000-0001-5665-1572</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2287-4208
ispartof The world journal of men's health, 2022-07, Vol.40 (3), p.347-360
issn 2287-4208
2287-4690
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_93d331e2c22445abb5941164b4b1acf7
source Publicly Available Content Database; PubMed Central
subjects abnormality
In vitro fertilization
Infertility
Laboratories
Life Sciences
Morphology
Motility
Quality control
Reproductive Biology
Reproductive technologies
Review
Sperm
stain
Stains & staining
teratozoospermia
title Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T17%3A58%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sperm%20Morphology%20Assessment%20in%20the%20Era%20of%20Intracytoplasmic%20Sperm%20Injection:%20Reliable%20Results%20Require%20Focus%20on%20Standardization,%20Quality%20Control,%20and%20Training&rft.jtitle=The%20world%20journal%20of%20men's%20health&rft.au=Agarwal,%20Ashok&rft.date=2022-07-01&rft.volume=40&rft.issue=3&rft.spage=347&rft.epage=360&rft.pages=347-360&rft.issn=2287-4208&rft.eissn=2287-4690&rft_id=info:doi/10.5534/wjmh.210054&rft_dat=%3Cproquest_doaj_%3E2814337646%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c509t-17d4f89cc8c3b468568fa44ce3f702be36a9101499724564b4f9cd92470d4fc23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2814337646&rft_id=info:pmid/34169687&rfr_iscdi=true