Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury

(Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni Multiflori Caulis (PMC). The hepatotoxicity of RPM and PMP is concerned by the p...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2022-04, Vol.13, p.868327
Main Authors: Kong, Wei-Song, Zhou, Gui, Xu, Li-Wei, Wang, Kun, Feng, Yi-Ming, Tao, Li-Yu, Xie, Rui-Fang, Yang, Ming, Zhou, Xin
Format: Article
Language:English
Subjects:
2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside
HPLC
liver injury
Pharmacology
Polygoni Multiflori Caulis
Polygonum multiflorum Thunb
real world
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni Multiflori Caulis (PMC). The hepatotoxicity of RPM and PMP is concerned by the public, while the risk of PMC is ignored. Here, we investigate the potential risks for PMC-induced liver injury from clinical, chemical, and animal features. First, we analyzed the 12-month usage of RPM, PMP, and PMC in Longhua Hospital. Second, we determined the contents of gallic acid, -2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ( -SG), -2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ( -SG), emodin-8-O-β-D-glucoside (EG), physcion-8-O-β-D-glucoside (PG), emodin, and physcion in the water extracts from 15 batches of RPM, PMP, and PMC. Third, we probed the hepatotoxic effect of RPM, PMP, and PMC in mice and explored the mechanism of -SG and -SG causing the liver injury at the dosages based on our results from the first and second parts. PMC had nearly five times the amount of usage in both outpatient prescriptions and inpatient orders than RPM and PMP. Overall, 68% dosage of PMC was 30 g. The contents of -SG, -SG, and emodin in PMC water extracts were significantly lower than those in RPM and PMP water extracts. PMC induced milder idiosyncratic liver injury for its lower content of -SG and -SG than its root counterparts. The potential risks for PMC-induced liver injury should be fully aware of.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.868327