Comparing the EQ-5D-5L and stroke impact scale 2.0 in stroke patients: an analysis of measurement properties

• Published in: Health and quality of life outcomes 2024-06, Vol.22 (1), p.45-45, Article 45
• Main Authors: Schmidt, Juliana, Düvel, Juliane Andrea, Elkenkamp, Svenja, Greiner, Wolfgang
• Format: Article
• Language: English
• Subjects: Activities of daily living; Adult; Aged; Analysis; Care and treatment; Ceilings; Chronic diseases; Clinical outcomes; Clinical trials; Comorbidity; Comparative analysis; Diagnosis; EQ-5D-5L; Feasibility; Female; Germany; Health-related quality of life; Hemorrhage; Humans; Ischemia; Ischemic Attack, Transient - psychology; Male; Measurement; Medical research; Medicine, Experimental; Middle Aged; Pandemics; Patients; Psychometrics; Public health; Quality of life; Quality of Life - psychology; Quantitative psychology; Quasi-experimental methods; Questionnaires; Reproducibility of Results; Self Report; SIS; Stroke; Stroke (Disease); Stroke - psychology; Stroke patients; Surveys and Questionnaires - standards; Transient ischemic attack
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-024-02252-z

Stroke has evolved to become a chronic disease and a major public health challenge. To adequately capture the full disease burden of stroke patients, the assessment of health-related quality of life (HRQoL) and thus the performance of respective measures is increasingly relevant. The aim of this analysis was to compare the measurement properties of two self-report instruments, the EQ-5D-5L and the Stroke Impact Scale 2.0. The data used for the analysis was derived from a quasi-experimental case management study for mildly to moderately affected incident stroke and transient ischemic attack (TIA) patients aged ≥ 18 in Germany. Data was collected patient-individually at 3, 6 and 12 months after initial stroke. The EQ-5D-5L and SIS 2.0 were compared in terms of feasibility, ceiling and floor effects, responsiveness and known-groups validity (Kruskal-Wallis H and Wilcoxon rank-sum test). A response for all three follow-ups is available for n = 855 patients. The feasibility of the EQ-5D-5L is determined as good (completion rate: 96.4-96.6%, ≥ one item missing: 3.2 - 3.3%), whereas the SIS 2.0 is moderately feasible (overall completion rate: 44.9-46.1%, ≥ one item missing in domains: 4.7 - 28.7%). The SIS 2.0 shows substantial ceiling effects in comparable domains (physical function: 10.4 - 13%, others: 3.5-31.3%) which are mainly larger than ceiling effects in the EQ-5D-5L index (17.1-21.5%). In terms of responsiveness, the EQ-5D-5L shows small to moderate change while the SIS 2.0 presents with moderate to large responsiveness. The EQ-5D-5L index, mobility, usual activities and Visual Analogue Scale show known-groups validity (p