12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study

• Published in: Frontiers in cellular and infection microbiology 2022-04, Vol.12, p.864933-864933
• Main Authors: Liao, Xuejiao, Li, Dapeng, Ma, Zhenghua, Zhang, Lina, Zheng, Baoqi, Li, Zhiyan, Li, Guobao, Liu, Lei, Zhang, Zheng
• Format: Article
• Language: English
• Subjects: Aftercare; alanine aminotransferase (ALT); albumin; aspartate aminotransferase (AST); Cellular and Infection Microbiology; COVID-19; gamma-glutamyltransferase (GGT); Humans; Liver Diseases; Liver Function Tests; Patient Discharge; Prospective Studies; SARS-CoV-2
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2022.864933

The longitudinal effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the liver are unknown. This study aimed to characterize dynamic changes in liver function test abnormalities in patients with COVID-19 at the acute phase and recovery phase. A prospective cohort study involved patients with COVID-19 who were admitted to Shenzhen Third People's Hospital between January 11, 2020, and April 27, 2020. Patients underwent liver function tests at hospitalization and at the outpatient visit at the 1-month, 3-month, 6-month, and 12-month follow-ups. Among 461 patients, 28.4% of patients had any kind of liver function tests abnormality at admission, manifested as elevated ALT (13.0%), AST (17.6%), and GGT (15.8%) levels. The trajectory analysis indicated a marked improvement in liver function after discharge, with any kind of liver function test abnormalities of 25.1% at 1 month, 13.2% at 3 months, 16.7% at 6 months, and 13.2% at 12 months after discharge. Persistent liver function abnormalities were observed in patients with pre-existing conditions during follow-up. A significantly higher prevalence of ultrasound determined fatty liver disease was found in those patients with more frequent LFT abnormalities at follow-up. In this study of patients with COVID-19, liver damage in COVID-19 was usually temporary and could return to normal at the end of the 12-month follow-up.