Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets

Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate treatment of brain tumors. Long non-coding RNAs...

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Published in:Journal of hematology and oncology 2021-05, Vol.14 (1), p.77-77, Article 77
Main Authors: Kim, Sung-Hyun, Lim, Key-Hwan, Yang, Sumin, Joo, Jae-Yeol
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Autophagy
Brain cancer
Brain disease
Brain tumors
Cancer
Cell adhesion & migration
Cell cycle
Cell growth
Chemotherapy
Chromosomes
Clinical trials
Epigenetic inheritance
Epigenetics
Gene expression
Genes
Genetic aspects
Genetic transcription
Genomes
Genomics
Glioma
Gliomas
Growth factors
Health aspects
Hematology
Kinases
LncRNA
Medical prognosis
Metastasis
MicroRNAs
Molecular modelling
Nervous system
Neurodegenerative disease
Non-coding RNA
Nucleotides
Oncology
Oncology, Experimental
Photodynamic therapy
Post-transcription
Proteins
Radiation therapy
Review
RNA
Signal transduction
Tumorigenesis
Tumors
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description Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate treatment of brain tumors. Long non-coding RNAs (lncRNAs), a type of non-coding RNA longer than 200 nucleotides, regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels and are involved in a variety of biological functions. Recent studies on lncRNAs have revealed their aberrant expression in various cancers, with distinct expression patterns associated with their instrumental roles in cancer. Abnormal expression of lncRNAs has also been identified in brain tumors. Here, we review the potential roles of lncRNAs and their biological functions in the context of brain tumors. We also summarize the current understanding of the molecular mechanisms and signaling pathways related to lncRNAs that may guide clinical trials for brain tumor therapy.
doi_str_mv 10.1186/s13045-021-01088-0
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subjects Angiogenesis
Apoptosis
Autophagy
Brain cancer
Brain disease
Brain tumors
Cancer
Cell adhesion & migration
Cell cycle
Cell growth
Chemotherapy
Chromosomes
Clinical trials
Epigenetic inheritance
Epigenetics
Gene expression
Genes
Genetic aspects
Genetic transcription
Genomes
Genomics
Glioma
Gliomas
Growth factors
Health aspects
Hematology
Kinases
LncRNA
Medical prognosis
Metastasis
MicroRNAs
Molecular modelling
Nervous system
Neurodegenerative disease
Non-coding RNA
Nucleotides
Oncology
Oncology, Experimental
Photodynamic therapy
Post-transcription
Proteins
Radiation therapy
Review
RNA
Signal transduction
Tumorigenesis
Tumors
title Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets
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