Three cases of vulvovaginal candidiasis due to Candida nivariensis

Candida nivariensis is emerging as a highly resistant species of the Candida glabrata complex causing invasive and mucocutaneous infections. In this study, three cases of vulvovaginal candidiasis caused by C. nivariensis are described and identified by Internal Transcribed Spacer 1–2 sequencing. All...

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Bibliographic Details
Published in:Medical mycology case reports 2024-03, Vol.43, p.100640-100640, Article 100640
Main Authors: Ton Nu, Phuong Anh, Ngo, Thi Minh Chau, Le Chi, Cao, Do, Thị Bich Thao, Tran Thi, Giang, Ha, Thị Ngoc Thuy, Nguyen, Phuoc Vinh, Le, Minh Tam
Format: Article
Language:English
Subjects:
Candida nivariensis
Case Series
Fluconazole
Vulvovaginal candidiasis
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Summary:Candida nivariensis is emerging as a highly resistant species of the Candida glabrata complex causing invasive and mucocutaneous infections. In this study, three cases of vulvovaginal candidiasis caused by C. nivariensis are described and identified by Internal Transcribed Spacer 1–2 sequencing. All isolates were susceptible in vitro to anidulafungin, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, amphotericin B, and showed dose-dependent susceptibility to fluconazole. In two patients, three doses of oral fluconazole were effective, while one patient developed clinical fluconazole resistance with a new relapse after 6 months. Increasing the weekly dose of fluconazole showed to be effective in this patient.
ISSN:2211-7539
2211-7539
DOI:10.1016/j.mmcr.2024.100640