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Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities
Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters...
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| Published in: | Frontiers in cellular and infection microbiology 2021-11, Vol.11, p.789919-789919 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 789919 |
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| container_title | Frontiers in cellular and infection microbiology |
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| creator | Wang, Bing-Yan Lu, Tom Cai, Qiuyin Ho, Meng-Hsuan Sheng, Sally Meng, Hsiu-Wan Arsto, Laura Hong, Jianming Xie, Hua |
| description | Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters of these patients retrospectively using axiUm and performed statistical analysis using SAS 9.4. We found that in this patient cohort, neighborhood median incomes were significantly higher among Caucasians Americans (CAs) than among African Americans (AAs) and Hispanic Americans (HAs). Levels of total bacteria and
, a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that
reduces
virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of
to
to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of
and lower ratios of
to
may contribute to periodontal health disparities. |
| doi_str_mv | 10.3389/fcimb.2021.789919 |
| format | article |
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, a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that
reduces
virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of
to
to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of
and lower ratios of
to
may contribute to periodontal health disparities.</description><identifier>ISSN: 2235-2988</identifier><identifier>EISSN: 2235-2988</identifier><identifier>DOI: 10.3389/fcimb.2021.789919</identifier><identifier>PMID: 34869082</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Cellular and Infection Microbiology ; Humans ; microbial profiles ; periodontitis ; Periodontitis - epidemiology ; Porphyromonas gingivalis ; Porphyromonas gingivalis - genetics ; racial and ethnic groups ; Retrospective Studies ; Risk Factors ; Streptococcus cristatus ; Virulence</subject><ispartof>Frontiers in cellular and infection microbiology, 2021-11, Vol.11, p.789919-789919</ispartof><rights>Copyright © 2021 Wang, Lu, Cai, Ho, Sheng, Meng, Arsto, Hong and Xie.</rights><rights>Copyright © 2021 Wang, Lu, Cai, Ho, Sheng, Meng, Arsto, Hong and Xie 2021 Wang, Lu, Cai, Ho, Sheng, Meng, Arsto, Hong and Xie</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-808bf4ac634bfe450abd1568c1e610fa0cd21fbff90ae0bdc048b108a3dfa48b3</citedby><cites>FETCH-LOGICAL-c465t-808bf4ac634bfe450abd1568c1e610fa0cd21fbff90ae0bdc048b108a3dfa48b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637773/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637773/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34869082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bing-Yan</creatorcontrib><creatorcontrib>Lu, Tom</creatorcontrib><creatorcontrib>Cai, Qiuyin</creatorcontrib><creatorcontrib>Ho, Meng-Hsuan</creatorcontrib><creatorcontrib>Sheng, Sally</creatorcontrib><creatorcontrib>Meng, Hsiu-Wan</creatorcontrib><creatorcontrib>Arsto, Laura</creatorcontrib><creatorcontrib>Hong, Jianming</creatorcontrib><creatorcontrib>Xie, Hua</creatorcontrib><title>Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities</title><title>Frontiers in cellular and infection microbiology</title><addtitle>Front Cell Infect Microbiol</addtitle><description>Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters of these patients retrospectively using axiUm and performed statistical analysis using SAS 9.4. We found that in this patient cohort, neighborhood median incomes were significantly higher among Caucasians Americans (CAs) than among African Americans (AAs) and Hispanic Americans (HAs). Levels of total bacteria and
, a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that
reduces
virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of
to
to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of
and lower ratios of
to
may contribute to periodontal health disparities.</description><subject>Cellular and Infection Microbiology</subject><subject>Humans</subject><subject>microbial profiles</subject><subject>periodontitis</subject><subject>Periodontitis - epidemiology</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - genetics</subject><subject>racial and ethnic groups</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Streptococcus cristatus</subject><subject>Virulence</subject><issn>2235-2988</issn><issn>2235-2988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1PVDEUhhujEYL8ADfmLt3MePpxe9uNCUEREozEaFw2p19D8c50bDsm_nsLgwjd9PT0fd_T9CHkNYUl50q_iy6t7ZIBo8tJaU31M3LIGB8XTCv1_FF9QI5rvYG-JmBK85fkgAslNSh2SFZXuYVNSzgPn5Mr2aY851Vy_fw11Z_DGbqWSx1Oas0uYQt--JHa9XAVSso-d2dLdcCN_9_p1vOAcxd9SHWLpStCfUVeRJxrOL7fj8j3s4_fTs8Xl18-XZyeXC6ckGNbKFA2CnSSCxuDGAGtp6NUjgZJISI4z2i0MWrAANY7EMpSUMh9xF7yI3Kxz_UZb8y2pDWWPyZjMneNXFYGS0tuDkYL0KN2YK1lIvRRDj1T1EWnhOMw9az3-6ztzq6Dd_2fCs5PQp_ebNK1WeXfRkk-TRPvAW_vA0r-tQu1mXWqLswzbkLeVcNknwIghexSupd2BrWWEB_GUDC3vM0db3PL2-x5d8-bx-97cPyjy_8Cau-q_w</recordid><startdate>20211117</startdate><enddate>20211117</enddate><creator>Wang, Bing-Yan</creator><creator>Lu, Tom</creator><creator>Cai, Qiuyin</creator><creator>Ho, Meng-Hsuan</creator><creator>Sheng, Sally</creator><creator>Meng, Hsiu-Wan</creator><creator>Arsto, Laura</creator><creator>Hong, Jianming</creator><creator>Xie, Hua</creator><general>Frontiers Media S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211117</creationdate><title>Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities</title><author>Wang, Bing-Yan ; Lu, Tom ; Cai, Qiuyin ; Ho, Meng-Hsuan ; Sheng, Sally ; Meng, Hsiu-Wan ; Arsto, Laura ; Hong, Jianming ; Xie, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-808bf4ac634bfe450abd1568c1e610fa0cd21fbff90ae0bdc048b108a3dfa48b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cellular and Infection Microbiology</topic><topic>Humans</topic><topic>microbial profiles</topic><topic>periodontitis</topic><topic>Periodontitis - epidemiology</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - genetics</topic><topic>racial and ethnic groups</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Streptococcus cristatus</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bing-Yan</creatorcontrib><creatorcontrib>Lu, Tom</creatorcontrib><creatorcontrib>Cai, Qiuyin</creatorcontrib><creatorcontrib>Ho, Meng-Hsuan</creatorcontrib><creatorcontrib>Sheng, Sally</creatorcontrib><creatorcontrib>Meng, Hsiu-Wan</creatorcontrib><creatorcontrib>Arsto, Laura</creatorcontrib><creatorcontrib>Hong, Jianming</creatorcontrib><creatorcontrib>Xie, Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Frontiers in cellular and infection microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bing-Yan</au><au>Lu, Tom</au><au>Cai, Qiuyin</au><au>Ho, Meng-Hsuan</au><au>Sheng, Sally</au><au>Meng, Hsiu-Wan</au><au>Arsto, Laura</au><au>Hong, Jianming</au><au>Xie, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities</atitle><jtitle>Frontiers in cellular and infection microbiology</jtitle><addtitle>Front Cell Infect Microbiol</addtitle><date>2021-11-17</date><risdate>2021</risdate><volume>11</volume><spage>789919</spage><epage>789919</epage><pages>789919-789919</pages><issn>2235-2988</issn><eissn>2235-2988</eissn><abstract>Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters of these patients retrospectively using axiUm and performed statistical analysis using SAS 9.4. We found that in this patient cohort, neighborhood median incomes were significantly higher among Caucasians Americans (CAs) than among African Americans (AAs) and Hispanic Americans (HAs). Levels of total bacteria and
, a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that
reduces
virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of
to
to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of
and lower ratios of
to
may contribute to periodontal health disparities.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>34869082</pmid><doi>10.3389/fcimb.2021.789919</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central |
| subjects | Cellular and Infection Microbiology Humans microbial profiles periodontitis Periodontitis - epidemiology Porphyromonas gingivalis Porphyromonas gingivalis - genetics racial and ethnic groups Retrospective Studies Risk Factors Streptococcus cristatus Virulence |
| title | Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities |
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