Genome-wide association analysis of composite sleep health scores in 413,904 individuals

Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct do...

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Bibliographic Details
Published in:Communications biology 2025-01, Vol.8 (1), p.115-15, Article 115
Main Authors: Goodman, Matthew O., Faquih, Tariq, Paz, Valentina, Nagarajan, Pavithra, Lane, Jacqueline M., Spitzer, Brian, Maher, Matthew, Chung, Joon, Cade, Brian E., Purcell, Shaun M., Zhu, Xiaofeng, Noordam, Raymond, Phillips, Andrew J. K., Kyle, Simon D., Spiegelhalder, Kai, Weedon, Michael N., Lawlor, Deborah A., Rotter, Jerome I., Taylor, Kent D., Isasi, Carmen R., Sofer, Tamar, Dashti, Hassan S., Rutter, Martin K., Redline, Susan, Saxena, Richa, Wang, Heming
Format: Article
Language:English
Subjects:
45/43
631/208/205/2138
692/617/375/1816
Adult
Association analysis
Biomedical and Life Sciences
Female
Gene loci
Genetic analysis
Genetic diversity
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomic analysis
Heritability
Humans
Insomnia
Life Sciences
Male
Middle Aged
Phenotypes
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
Sleep
Sleep - genetics
Sleep and wakefulness
Sleep disorders
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Summary:Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p 
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-025-07514-0