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CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis
The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease. We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challeng...
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| Published in: | Nutrients 2019-10, Vol.11 (11), p.2551 |
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| container_title | Nutrients |
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| creator | Fernández-Prieto, Marta Fernández-Aceñero, María Jesús López-Palacios, Natalia Bodas, Andrés Farrais, Sergio Cuevas, David Pascual, Virginia Cerón-Nieto, M Ángeles Horta-Herrera, Saúl Espino-Paisán, Laura Salazar, Isabel Núñez, Concepción |
| description | The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease.
We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challenge, to study soluble CX3CL1, I-TAC and MIG by Luminex,
and
gene expression by qPCR, and CX3CR1 protein expression in monocytes and CD8
, CD4
and γδ
T cells, by flow cytometry. We also analysed the expression of the
and
mRNA and protein in the duodenal biopsies of CD patients with active and treated disease, and in non-CD control individuals, by qPCR and immunohistochemistry.
After the gluten challenge, increased levels of CX3CL1, I-TAC and MIG proteins were observed in the peripheral blood of CD patients, with no changes in
mRNA, or
mRNA and protein. Regarding duodenal tissue, CX3CL1 was absent or barely present in the superficial and basal epithelium of CD patients, contrasting with the moderate to high levels present in controls.
CX3CL1 seems to be involved in the appearance and progression of CD, and it appears to be a potential diagnostic biomarker. Its use as an alternative therapeutic target in CD deserves further research. |
| doi_str_mv | 10.3390/nu11112551 |
| format | article |
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We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challenge, to study soluble CX3CL1, I-TAC and MIG by Luminex,
and
gene expression by qPCR, and CX3CR1 protein expression in monocytes and CD8
, CD4
and γδ
T cells, by flow cytometry. We also analysed the expression of the
and
mRNA and protein in the duodenal biopsies of CD patients with active and treated disease, and in non-CD control individuals, by qPCR and immunohistochemistry.
After the gluten challenge, increased levels of CX3CL1, I-TAC and MIG proteins were observed in the peripheral blood of CD patients, with no changes in
mRNA, or
mRNA and protein. Regarding duodenal tissue, CX3CL1 was absent or barely present in the superficial and basal epithelium of CD patients, contrasting with the moderate to high levels present in controls.
CX3CL1 seems to be involved in the appearance and progression of CD, and it appears to be a potential diagnostic biomarker. Its use as an alternative therapeutic target in CD deserves further research.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu11112551</identifier><identifier>PMID: 31652730</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Adult ; Celiac disease ; Celiac Disease - genetics ; Celiac Disease - immunology ; Celiac Disease - metabolism ; Chemokine CX3CL1 - genetics ; Chemokine CX3CL1 - metabolism ; Chemokines ; coeliac disease ; CX3C Chemokine Receptor 1 - genetics ; CX3C Chemokine Receptor 1 - metabolism ; cx3cl1 ; cx3cr1 ; CX3CR1 protein ; Cytokines ; Diagnosis ; Diagnostic systems ; Diet ; Disease ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; fractalkine ; Gastroenterology ; Gene expression ; Gene Expression Regulation - physiology ; Genetic Predisposition to Disease ; Gluten ; Glutens - immunology ; Humans ; Hypersensitivity - immunology ; Immunoglobulins ; Immunohistochemistry ; Inflammation ; Lymphocytes ; Lymphocytes T ; Male ; Middle Aged ; Nutrition ; Paraffins ; Pediatrics ; Proteins ; Young Adult ; γ-Interferon</subject><ispartof>Nutrients, 2019-10, Vol.11 (11), p.2551</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-bb21e312c67e2a68523abe8929d31dd95fd3bcc45ac23a6176fe5643614aa06a3</citedby><cites>FETCH-LOGICAL-c472t-bb21e312c67e2a68523abe8929d31dd95fd3bcc45ac23a6176fe5643614aa06a3</cites><orcidid>0000-0002-1605-5407 ; 0000-0002-9489-1603</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2315480736/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2315480736?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31652730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Prieto, Marta</creatorcontrib><creatorcontrib>Fernández-Aceñero, María Jesús</creatorcontrib><creatorcontrib>López-Palacios, Natalia</creatorcontrib><creatorcontrib>Bodas, Andrés</creatorcontrib><creatorcontrib>Farrais, Sergio</creatorcontrib><creatorcontrib>Cuevas, David</creatorcontrib><creatorcontrib>Pascual, Virginia</creatorcontrib><creatorcontrib>Cerón-Nieto, M Ángeles</creatorcontrib><creatorcontrib>Horta-Herrera, Saúl</creatorcontrib><creatorcontrib>Espino-Paisán, Laura</creatorcontrib><creatorcontrib>Salazar, Isabel</creatorcontrib><creatorcontrib>Núñez, Concepción</creatorcontrib><title>CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease.
We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challenge, to study soluble CX3CL1, I-TAC and MIG by Luminex,
and
gene expression by qPCR, and CX3CR1 protein expression in monocytes and CD8
, CD4
and γδ
T cells, by flow cytometry. We also analysed the expression of the
and
mRNA and protein in the duodenal biopsies of CD patients with active and treated disease, and in non-CD control individuals, by qPCR and immunohistochemistry.
After the gluten challenge, increased levels of CX3CL1, I-TAC and MIG proteins were observed in the peripheral blood of CD patients, with no changes in
mRNA, or
mRNA and protein. Regarding duodenal tissue, CX3CL1 was absent or barely present in the superficial and basal epithelium of CD patients, contrasting with the moderate to high levels present in controls.
CX3CL1 seems to be involved in the appearance and progression of CD, and it appears to be a potential diagnostic biomarker. Its use as an alternative therapeutic target in CD deserves further research.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Celiac disease</subject><subject>Celiac Disease - genetics</subject><subject>Celiac Disease - immunology</subject><subject>Celiac Disease - metabolism</subject><subject>Chemokine CX3CL1 - genetics</subject><subject>Chemokine CX3CL1 - metabolism</subject><subject>Chemokines</subject><subject>coeliac disease</subject><subject>CX3C Chemokine Receptor 1 - genetics</subject><subject>CX3C Chemokine Receptor 1 - metabolism</subject><subject>cx3cl1</subject><subject>cx3cr1</subject><subject>CX3CR1 protein</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Diet</subject><subject>Disease</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>fractalkine</subject><subject>Gastroenterology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genetic Predisposition to Disease</subject><subject>Gluten</subject><subject>Glutens - immunology</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Paraffins</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Young Adult</subject><subject>γ-Interferon</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkd9rFDEQgIMotrR98Q-QBV9EWJsfm2TXB_HYals4tIiCb2GSnb3m2Nu0ya62_705r9bWeZkw8_ExkyHkBaNvhWjo8TizHFxK9oTsc6p5qVQlnj5475GjlNZ0G5pqJZ6TPcGU5FrQffKh_SHaJSu36SsrFjc-vSsWxWf8VVwMcIux8GPRBhw8uOLEJ4SExQVMl2GFIyafDsmzHoaER3f5gHz_9PFbe1Yuv5yet4tl6SrNp9JazlAw7pRGDqqWXIDFuuFNJ1jXNbLvhHWukuByRzGtepR5eMUqAKpAHJDznbcLsDZX0W8g3poA3vwphLgyECfvBjRNxSVjeXW0vGIMGtvnAtoahG0U7bLr_c51NdsNdg7HKcLwSPq4M_pLswo_jaobkeVZ8PpOEMP1jGkyG58cDgOMGOZkuKCNpFozndFX_6HrMMcxf1WmmKxqqoXK1Jsd5WJIKWJ_PwyjZntn8-_OGX75cPx79O9VxW_4zZ5t</recordid><startdate>20191023</startdate><enddate>20191023</enddate><creator>Fernández-Prieto, Marta</creator><creator>Fernández-Aceñero, María Jesús</creator><creator>López-Palacios, Natalia</creator><creator>Bodas, Andrés</creator><creator>Farrais, Sergio</creator><creator>Cuevas, David</creator><creator>Pascual, Virginia</creator><creator>Cerón-Nieto, M Ángeles</creator><creator>Horta-Herrera, Saúl</creator><creator>Espino-Paisán, Laura</creator><creator>Salazar, Isabel</creator><creator>Núñez, Concepción</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1605-5407</orcidid><orcidid>https://orcid.org/0000-0002-9489-1603</orcidid></search><sort><creationdate>20191023</creationdate><title>CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis</title><author>Fernández-Prieto, Marta ; Fernández-Aceñero, María Jesús ; López-Palacios, Natalia ; Bodas, Andrés ; Farrais, Sergio ; Cuevas, David ; Pascual, Virginia ; Cerón-Nieto, M Ángeles ; Horta-Herrera, Saúl ; Espino-Paisán, Laura ; Salazar, Isabel ; Núñez, Concepción</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-bb21e312c67e2a68523abe8929d31dd95fd3bcc45ac23a6176fe5643614aa06a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Celiac disease</topic><topic>Celiac Disease - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Prieto, Marta</au><au>Fernández-Aceñero, María Jesús</au><au>López-Palacios, Natalia</au><au>Bodas, Andrés</au><au>Farrais, Sergio</au><au>Cuevas, David</au><au>Pascual, Virginia</au><au>Cerón-Nieto, M Ángeles</au><au>Horta-Herrera, Saúl</au><au>Espino-Paisán, Laura</au><au>Salazar, Isabel</au><au>Núñez, Concepción</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2019-10-23</date><risdate>2019</risdate><volume>11</volume><issue>11</issue><spage>2551</spage><pages>2551-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The CX3CL1-CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease.
We collected peripheral blood from CD patients and controls, enrolled in a 3-day gluten challenge, to study soluble CX3CL1, I-TAC and MIG by Luminex,
and
gene expression by qPCR, and CX3CR1 protein expression in monocytes and CD8
, CD4
and γδ
T cells, by flow cytometry. We also analysed the expression of the
and
mRNA and protein in the duodenal biopsies of CD patients with active and treated disease, and in non-CD control individuals, by qPCR and immunohistochemistry.
After the gluten challenge, increased levels of CX3CL1, I-TAC and MIG proteins were observed in the peripheral blood of CD patients, with no changes in
mRNA, or
mRNA and protein. Regarding duodenal tissue, CX3CL1 was absent or barely present in the superficial and basal epithelium of CD patients, contrasting with the moderate to high levels present in controls.
CX3CL1 seems to be involved in the appearance and progression of CD, and it appears to be a potential diagnostic biomarker. Its use as an alternative therapeutic target in CD deserves further research.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31652730</pmid><doi>10.3390/nu11112551</doi><orcidid>https://orcid.org/0000-0002-1605-5407</orcidid><orcidid>https://orcid.org/0000-0002-9489-1603</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2019-10, Vol.11 (11), p.2551 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Adolescent Adult Celiac disease Celiac Disease - genetics Celiac Disease - immunology Celiac Disease - metabolism Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Chemokines coeliac disease CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism cx3cl1 cx3cr1 CX3CR1 protein Cytokines Diagnosis Diagnostic systems Diet Disease Enzyme-linked immunosorbent assay Enzymes Female fractalkine Gastroenterology Gene expression Gene Expression Regulation - physiology Genetic Predisposition to Disease Gluten Glutens - immunology Humans Hypersensitivity - immunology Immunoglobulins Immunohistochemistry Inflammation Lymphocytes Lymphocytes T Male Middle Aged Nutrition Paraffins Pediatrics Proteins Young Adult γ-Interferon |
| title | CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis |
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