Telomere Length as a Biomarker of Biological Aging in Shift Workers

Shift work (SW) comprises a work schedule that involves recurring times of nonstandard work hours balanced to a fixed daily work plan with regular day work times and has been evaluated as “probably carcinogenic to humans” (Group 2A) by IARC. SW may result in increased age acceleration. This systemat...

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Bibliographic Details
Published in:Applied sciences 2020-04, Vol.10 (8), p.2764
Main Authors: Ledda, Caterina, Loreto, Carla, Rapisarda, Venerando
Format: Article
Language:English
Subjects:
Aging
Biomarkers
Carcinogens
Circadian rhythm
circadian rhythms
CLOCK gene
DNA methylation
inflammation
night work
Occupational health
Physicians
Precision medicine
Schedules
Shift work
Workers
Working conditions
Yeast
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Summary:Shift work (SW) comprises a work schedule that involves recurring times of nonstandard work hours balanced to a fixed daily work plan with regular day work times and has been evaluated as “probably carcinogenic to humans” (Group 2A) by IARC. SW may result in increased age acceleration. This systematic review aims to elucidate the usefulness of telomere length as a biomarker of biological aging in shift workers. All studies analyzed underline a shortening of telomere length in SW, and aging in shift workers and duration of work. Methodologies to measure biological aging are possible to advance efforts to clarify the basic biology of aging and provide clinicians an instrument to communicate complex health advice to workers. Telomere length measures can also give an instrument for precision medicine, useful for occupational physicians in age-related screening conditions.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10082764