A Free-Standing Chitosan Membrane Prepared by the Vibration-Assisted Solvent Casting Method

Much attention has been paid to the surface modification of artificial skin barriers for the treatment of skin tissue damage. Chitosan is one of the natural materials that could be characterized by its biocompatibility. A number of methods for the preparation of chitosan membranes have been describe...

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Bibliographic Details
Published in:Micromachines (Basel) 2023-07, Vol.14 (7), p.1419
Main Authors: Cigane, Urte, Palevicius, Arvydas, Janusas, Giedrius
Format: Article
Language:English
Subjects:
Acetic acid
Acids
Aluminum
Aluminum oxide
Analysis
Biocompatibility
Chitosan
chitosan membrane
Electrolytes
Finite element method
Flat surfaces
Fluid flow
Founding
Geometry
high-frequency excitation
Membranes
Methods
Nanomaterials
nanoporous AAO template
Skin
Skin care products
solvent casting method
Solvents
Surface area
Tissue engineering
two-step anodization method
Vibration
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Summary:Much attention has been paid to the surface modification of artificial skin barriers for the treatment of skin tissue damage. Chitosan is one of the natural materials that could be characterized by its biocompatibility. A number of methods for the preparation of chitosan membranes have been described in scientific articles, including solvent casting methods. This study investigates an improved technology to produce chitosan membranes. Thus, chitosan membranes were prepared using a vibration-assisted solvent casting method. First, aqueous acetic acid was used to pretreat chitosan. Then, free-standing chitosan membranes were prepared by solvent casting on nanoporous anodized aluminum oxide (AAO) membrane templates, allowing for the solvent to evaporate. Using finite element methods, a study was obtained showing the influence of chitosan solutions of different concentrations on the fluid flow into nanopores using high-frequency excitation. The height of the nanopillars and the surface area of the chitosan membrane were also evaluated. In this study, the surface area of the chitosan membrane was found to increase by 15, 10 and 6 times compared to the original flat surface area. The newly produced nanopillared chitosan membranes will be applicable in the fabrication of skin barriers due to the longer nanopillars on their surface and the larger surface area.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi14071419