Red Cabbage Modulates Composition and Co-Occurrence Networks of Gut Microbiota in a Rodent Diet-Induced Obesity Model

• Published in: Foods 2023-12, Vol.13 (1), p.85
• Main Authors: Wu, Yanbei, Xin, Mengmeng, Pham, Quynhchi, Gao, Yu, Huang, Haiqiu, Jiang, Xiaojing, Li, Robert W, Yu, Liangli, Luo, Yaguang, Wang, Jing, Wang, Thomas T Y
• Format: Article
• Language: English
• Subjects: 16S rRNA sequencing; Analysis; Bacteria; Bile acids; Biological effects; Body weight; Body weight gain; Cardiovascular disease; Cholesterol; Chronic illnesses; Composition; Diet; Feces; gut microbiota; High fat diet; Immune system; Intestinal microflora; Lipid metabolism; Low density lipoproteins; Low fat diet; Metabolic disorders; Metabolic syndrome; mice obesity model; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Nutrient deficiency; Obesity; Physiology; Polyphenols; red cabbage; Relative abundance; Risk factors; Software; Type 2 diabetes
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods13010085

Red cabbage (RC), a cruciferous vegetable rich in various bioactive substances, can significantly reduce the risk factors of several non-communicable diseases, but the mechanism underlying the biological effects of RC remains unclear. Furthermore, mechanisms that operate through the regulation of gut microbiota also are not known. Given the relationships between diet, gut microbiota, and health, a diet-induced mice obesity model was used to elucidate the influence of RC on gut microbial composition and bacteria-bacteria interactions in mice. After 24 h of dietary intervention, a high-fat (HF) diet with the intake of RC led to increased Firmicutes/Bacteroidetes (F/B) ratios in the feces of mice. RC also reduced the relative abundance of , , and in mice fed a low-fat (LF) diet. After 8-weeks of dietary intervention, RC significantly changed the structure and the ecological network of the gut microbial community. Particularly, RC inhibited an HF-diet-induced increase in in mice, and this genus was positively correlated with body weight, low-density lipoprotein level, and fecal bile acid of mice. Unclassified , specifically increased via RC consumption, were also found to negatively correlate with hepatic free cholesterol levels in mice. Overall, our results demonstrated that RC modulating gut microbial composition and interactions are associated with the attenuation of HF-diet-induced body weight gain and altered cholesterol metabolism in mice.