Factors related to hypermetabolism in individuals with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Considering the progressive prevalence and co-occurrence of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), as well as the current evidence suggesting the elevated levels of basal metabolic rate (BMR) among these individuals, the present study aimed to identify factors...

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Published in:Scientific reports 2023-03, Vol.13 (1), p.3669-3669, Article 3669
Main Authors: Mansour, Asieh, Motamed, Soudabe, Hekmatdoost, Azita, Karimi, Sara, Mohajeri-Tehrani, Mohammad Reza, Abdollahi, Mohammad, Jelodar, Reihane, Sajjadi-Jazi, Sayed Mahmoud
Format: Article
Language:English
Subjects:
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Adiponectin
Adult
Alanine Transaminase
Blood pressure
Body mass index
Body water
Calorimetry
Cholesterol
Cross-Sectional Studies
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Dipeptidyl-Peptidase IV Inhibitors
Energy expenditure
Fatty liver
Female
Humanities and Social Sciences
Humans
Liver diseases
Male
Metabolic rate
Middle Aged
multidisciplinary
Non-alcoholic Fatty Liver Disease
Physical activity
Regression analysis
Science
Science (multidisciplinary)
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Summary:Considering the progressive prevalence and co-occurrence of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), as well as the current evidence suggesting the elevated levels of basal metabolic rate (BMR) among these individuals, the present study aimed to identify factors determining hypermetabolism in such subjects. This cross sectional study was conducted in 30 to 53-year-old individuals with concurrent T2DM and NAFLD (controlled attenuation parameter score ≥ 260 dB/m). Resting energy expenditure (REE) was determined by an indirect calorimetry device. Hypermetabolism was defined as an elevated measured REE > 110% of the predicted REE. The multivariate logistic regression test was used for detecting factors associated with hypermetabolism. Between September, 2017, and March, 2018, a total of 95 eligible participants (64.40% male) with both T2DM and NAFLD were included, while 32.63% of them were classified as hypermetabolic. Overall, the mean recruitment age ± standard deviation and median (interquartile range) body mass index were 44.69 ± 5.47 years and 30.20 (27.80–33.30) kg/m 2 , respectively. Demographic, anthropometric and biochemical variables did not vary significantly across two groups except for total body water, low-density lipoprotein cholesterol and dipeptidyl peptidase 4 (DPP-4) inhibitors (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30945-w