Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo

To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR a...

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Bibliographic Details
Published in:Emerging infectious diseases 2020-08, Vol.26 (8), p.1801-1809
Main Authors: Raja, Thamayanthi Nada, Hu, Ting Huey, Kadir, Khamisah Abdul, Mohamad, Dayang Shuaisah Awang, Rosli, Nawal, Wong, Lolita Lin, Hii, King Ching, Simon Divis, Paul Cliff, Singh, Balbir
Format: Article
Language:English
Subjects:
and
Cytochrome
Deoxyribonucleic acid
DNA
Ethics
Genomes
Infections
Infections, Malaysian Borneo
Laboratories
Malaria
Malaysian Borneo
Medical research
Mitochondrial DNA
Naturally Acquired Human
Oxidases
Parasites
parasitic diseases
Patients
Plasmodium cynomolgi
Plasmodium falciparum
Plasmodium knowlesi
Thermal cycling
Zoonoses
zoonosis
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Summary:To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30). We noted the annual number of these zoonotic infections increased greatly in 2017 (n = 284). We identified 6 patients, 17-65 years of age, with P. cynomolgi and P. knowlesi co-infections, confirmed by phylogenetic analyses of the Plasmodium cytochrome c oxidase subunit 1 gene sequences. P. knowlesi continues to be a public health concern in the Kapit Division of Sarawak, Malaysian Borneo. In addition, another simian malaria parasite, P. cynomolgi, also is an emerging cause of malaria in humans.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2608.200343