Insulin resistance in transgender individuals correlates with android fat mass

Background: Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance. Aims: To examine relationships between body fat distribution and insulin resistan...

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Bibliographic Details
Published in:Therapeutic advances in endocrinology and metabolism 2021-01, Vol.12, p.2042018820985681-2042018820985681
Main Authors: Bretherton, Ingrid, Spanos, Cassandra, Leemaqz, Shalem Y., Premaratne, Gehan, Grossmann, Mathis, Zajac, Jeffrey D., Cheung, Ada S.
Format: Article
Language:English
Subjects:
Body composition
Body fat
Cardiovascular diseases
Composition effects
Correlation coefficient
Correlation coefficients
Dual energy X-ray absorptiometry
Gender
Health risks
Homeostasis
Insulin
Insulin resistance
Men
Original Research
Transgender persons
Women
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Summary:Background: Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance. Aims: To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT. Methods: Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin Resistance (HOMA2-IR)] were made between transgender individuals (43 trans men and 41 trans women) on established GAHT (>12 months) and age-matched cisgender controls (30 males and 48 females). Multiple linear regressions were used to examine the relationship between HOMA2-IR and fat mass with gender, adjusting for age and total duration of GAHT and Pearson correlation coefficients are reported. Results: Compared with control cisgender women, trans men had mean difference of +7.8 kg (4.0, 11.5), p 
ISSN:2042-0188
2042-0196
DOI:10.1177/2042018820985681