Bacterial live therapeutics for human diseases

The genomic revolution has fueled rapid progress in synthetic and systems biology, opening up new possibilities for using live biotherapeutic products (LBP) to treat, attenuate or prevent human diseases. Among LBP, bacteria-based therapies are particularly promising due to their ability to colonize...

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Bibliographic Details
Published in:Molecular systems biology 2024-12, Vol.20 (12), p.1261-1281
Main Authors: Frutos-Grilo, Elisabet, Ana, Yamile, Gonzalez-de Miguel, Javier, Cardona-i-Collado, Marcel, Rodriguez-Arce, Irene, Serrano, Luis
Format: Article
Language:English
Subjects:
Animals
Bacteria - genetics
Bacteria - metabolism
Biological Therapy - methods
Biomedical and Life Sciences
Clinical Trials as Topic
EMBO23
EMBO41
Gastrointestinal Microbiome
Gut-Body Axis
Humans
Life Sciences
Live Therapeutic Products
Microbiota
On-Site Delivery
Pathogenic Bacteria
Review
Review Article
Systems Biology
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Summary:The genomic revolution has fueled rapid progress in synthetic and systems biology, opening up new possibilities for using live biotherapeutic products (LBP) to treat, attenuate or prevent human diseases. Among LBP, bacteria-based therapies are particularly promising due to their ability to colonize diverse human tissues, modulate the immune system and secrete or deliver complex biological products. These bacterial LBP include engineered pathogenic species designed to target specific diseases, and microbiota species that promote microbial balance and immune system homeostasis, either through local administration or the gut-body axes. This review focuses on recent advancements in preclinical and clinical trials of bacteria-based LBP, highlighting both on-site and long-reaching strategies. This Review discusses recent advancements in preclinical and clinical trials of bacteria-based live biotherapeutic products, highlighting both on-site and long-reaching strategies.
ISSN:1744-4292
1744-4292
DOI:10.1038/s44320-024-00067-0