Systemic lupus erythematosus in males : a case series

The reported prevalence of systemic lupus erythematosus (SLE) in the general population is 20–150 cases per 100,000 population. The female to male ratio ranges from 7–15:1. An estrogen effect has been suggested by a number of observations for this difference. In children, sex hormonal effects are pr...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2014-05, Vol.25 (3), p.638-642
Main Authors: Agrawaal, Krishna Kumar, Dhakal, Subodh Sagar
Format: Article
Language:English
Subjects:
Adult
Aged
Comorbidity
Demographic aspects
Diagnosis
Diseases
Distribution
Drug Therapy, Combination
Fatal Outcome
Humans
Immunosuppressive Agents - therapeutic use
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - therapy
Lupus Nephritis - complications
Lupus Nephritis - diagnosis
Lupus Nephritis - therapy
Male
Men
Nepal
Patient outcomes
Predictive Value of Tests
Renal Dialysis
Sex Factors
Systemic lupus erythematosus
Treatment Outcome
Young Adult
الأمراض
التشخيص
الذئبة الحمامية
الرجال
المرضى
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Summary:The reported prevalence of systemic lupus erythematosus (SLE) in the general population is 20–150 cases per 100,000 population. The female to male ratio ranges from 7–15:1. An estrogen effect has been suggested by a number of observations for this difference. In children, sex hormonal effects are presumably minimal and, thus, the female to male ratio is 3:1. We report a series of three male patients who presented at the B. P. Koirala Institute of Health Sciences and were diagnosed to have lupus nephritis (LN). This is probably the first case series from Nepal on adult male LN. Male patients with SLE present mainly with renal involvement and seizures rather than photophobia and skin manifestations. The outcome also seems to be more serious in males. Thus, we believe that although male patients with lupus are not commonly seen, the manifestations are life threatening and early detection of the disease will lead to better outcome of these patients.
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.132222