Closed loop fractional order drug delivery control scheme for chemotherapy

Chemotherapy is one of the most extensively utilized cancer treatment strategies worldwide. It is intended to eliminate fast-developing cancer cells in a patient’s body. The amount of chemotherapeutic drug that must be administered precisely into a patient’s body determines the efficacy of the treat...

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Bibliographic Details
Published in:Results in control and optimization 2022-03, Vol.6, p.100097, Article 100097
Main Authors: Pachauri, Nikhil, Yadav, Drishti, Sharma, Tarun Kumar, Verma, Om Prakash, Ahn, Chang Wook
Format: Article
Language:English
Subjects:
Chemotherapy
Drug concentration
FOIMC
FOPID
IPD
Whale optimization algorithm
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Summary:Chemotherapy is one of the most extensively utilized cancer treatment strategies worldwide. It is intended to eliminate fast-developing cancer cells in a patient’s body. The amount of chemotherapeutic drug that must be administered precisely into a patient’s body determines the efficacy of the treatment and governs the patient survival during chemotherapy. Therefore, controlling the chemotherapeutic drug dose delivered to the patient is essential. This research aims to propose a two-degree-of-freedom fractional order proportional–integral–derivative (2FOPID) controller with a set point filter for implementing an automatic drug delivery control scheme during chemotherapy. The Whale optimization algorithm (WOA) is used to tune the parameters of the 2FOPID controller, resulting in a WOA-tuned 2FOPID controller (W2FOPID). The performance of the proposed W2FOPID is compared with the Integral–Proportional–Derivative (IPD), Internal Model Control (IMC), and Fractional Order IMC (FOIMC) schemes. The experimental results demonstrate that the proposed W2FOPID controller is effective, accurate, and robust for drug concentration control during chemotherapy. W2FOPID outperforms IPD, IMC, and FOIMC schemes in terms of Integral Absolute Error by 79.9%, 25.3%, and 23.36%, respectively. In addition, W2FOPID exhibits excellent set-point tracking, noise suppression and uncertainty handling capabilities. •Design of a 2FOPID controller with setpoint filter for automatic drug delivery.•Estimation of 2FOPID controller parameters via Whale Optimization Algorithm (WOA).•Comparison of WOA towards controller design with other well-known algorithms.•Comparison of the WOA-tuned 2FOPID controller with other control techniques.
ISSN:2666-7207
2666-7207
DOI:10.1016/j.rico.2022.100097