DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases developing later in life, and epigenetic characterisation of pubertal timing and development coul...

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Bibliographic Details
Published in:Clinical epigenetics 2023-11, Vol.15 (1), p.181-181, Article 181
Main Authors: Sehovic, Emir, Zellers, Stephanie M, Youssef, Markus K, Heikkinen, Aino, Kaprio, Jaakko, Ollikainen, Miina
Format: Article
Language:English
Subjects:
Adult
Age
Analysis
Breasts
Children & youth
CpG Islands
Development and progression
Discordance
DNA
DNA Methylation
Environmental factors
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenomics
Female
Gender differences
Genes
Genetic aspects
Genomes
Genotypes
Hair
Heritability
Humans
Male
meQTL
Methylation
Ovarian cancer
Peripheral blood
Prostate
Prostate cancer
Puberty
Puberty - genetics
Quantitative genetics
Quantitative trait loci
Questionnaires
Sexes
Skin
Twin studies
Twins
Young adults
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Summary:Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases developing later in life, and epigenetic characterisation of pubertal timing and development could lead to important insights. Blood DNA methylation, reacting to both genotype and environment, has been associated with puberty; however, such studies are relatively scarce. We investigated peripheral blood DNA methylation profiles (using Illumina 450 K and EPIC platforms) of 1539 young adult Finnish twins associated with pubertal development scale (PDS) at ages 12 and 14 as well as pubertal age (PA). Fixed effect meta-analysis of the two platforms on 347,521 CpGs in common identified 58 CpG sites associated (p 
ISSN:1868-7083
1868-7075
1868-7083
1868-7075
DOI:10.1186/s13148-023-01594-7