Novel inflammatory and insulin resistance indices provide a clue in cerebral amyloid angiopathy

This study investigated the correlation of newly identified inflammatory and insulin resistance indices with cerebral amyloid angiopathy (CAA), and explored their potential to differentiate CAA from hypertensive arteriopathy (HA). We retrospectively analyzed 514 consecutive patients with cerebral sm...

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Bibliographic Details
Published in:Scientific reports 2024-05, Vol.14 (1), p.11474-11474, Article 11474
Main Authors: Zhu, Hang-hang, Wang, Yun-chao, He, Liu-chang, Luo, Hai-yang, Zong, Ce, Yang, Ying-hao, Wu, Jing-Hao, Song, Bo, Gao, Yuan, Xu, Yu-ming, Li, Yu-sheng
Format: Article
Language:English
Subjects:
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Aged
Amyloid
Biomarkers - blood
Cerebral amyloid angiopathy
Cerebral Amyloid Angiopathy - pathology
Cerebral small vessel disease
Cerebral Small Vessel Diseases - blood
Cerebral Small Vessel Diseases - pathology
Female
Hemorrhage
Humanities and Social Sciences
Humans
Hypertensive arteriopathy
Inflammation
Inflammation - pathology
Insulin Resistance
Leukocytes (neutrophilic)
Lymphocytes
Lymphocytes - metabolism
Male
Middle Aged
multidisciplinary
Neutrophils - metabolism
Neutrophil–lymphocyte ratio
Nomograms
Retrospective Studies
Science
Science (multidisciplinary)
Triglycerides - blood
Triglyceride–glucose index
Vascular diseases
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Summary:This study investigated the correlation of newly identified inflammatory and insulin resistance indices with cerebral amyloid angiopathy (CAA), and explored their potential to differentiate CAA from hypertensive arteriopathy (HA). We retrospectively analyzed 514 consecutive patients with cerebral small vessel disease (CSVD)-related haemorrhage, comparing the differences in novel inflammatory and insulin resistance indices between patients with CAA and HA. Univariate regression, LASSO and multivariate regression were used to screen variables and construct a classification diagnosis nomogram. Additionally, these biomarkers were explored in patients with mixed haemorrhagic CSVD. Inflammatory indices were higher in CAA patients, whereas insulin resistance indices were higher in HA patients. Further analysis identified neutrophil-to-lymphocyte ratio (NLR, OR 1.17, 95% CI 1.07–1.30, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-62280-z