An Original Asteraceae Based Infused Drink Prevents Metabolic Syndrome in Fructose-Rat Model

• Published in: Antioxidants 2023-01, Vol.12 (2), p.340
• Main Authors: Idres, Arezki Yanis, Tousch, Didier, Dhuyque-Mayer, Claudie, Hammad, Imane, Lambert, Karen, Cazals, Guillaume, Portet, Karine, Ferrare, Karine, Bidel, Luc P R, Poucheret, Patrick
• Format: Article
• Language: English
• Subjects: (Taraxacum officinale W.) leaves; Animals; Antioxidants; Arctium; Arctium lappa L. roots; Asteraceae; Beverages; bitter Asteraceae; Blood pressure; Body weight gain; Cardiovascular diseases; Chemical Sciences; Chicory; Chlorogenic acid; Chromatography; Compositae; Dental roots; Diabetes; Diabetes mellitus; Diet; Endocrinology and metabolism; Fructose; fructose-rat model; Glucose; Glucose tolerance; Glucose-6-phosphatase; Health aspects; Human health and pathology; Hyperglycemia; Hyperinsulinemia; Hypertriglyceridemia; Insulin; Insulin resistance; Ions; Life Sciences; Mass spectrometry; Materials; Medicinal Chemistry; Metabolic diseases; Metabolic syndrome; Natural foods; Oral administration; Oxidative stress; Prevention; Scientific imaging; Software
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox12020340

Metabolic syndrome (METS) is a complex disorder that predisposes an affected person to an increased risk of diabetes and cardiovascular disease. Bitter Asteraceae plants contain several compounds active against METS that can be used as an alternative preventive therapy. Our previous work showed that a natural chicory extract (NCRAE) containing chicoric acid (CRA) and chlorogenic acid (CGA) in a molar ratio of 70/30 exhibited an antioxidant, insulin sensitization and anti-hyperglycemic effect. The present study was designed to evaluate the preventive effects of an NCRAE-like extract against METS in a complementary natural pharmacotherapeutic approach. An original Asteraceae infused drink containing the NCRAE CRA/CGA molecular ratio equivalent was prepared from dandelion ( L.) and burdock ( L.). The anti-METS effect of this drink was evaluated on the fructose-rat model for 8 weeks. Body weight, blood biochemistry, hepatic glucose-6-phosphatase, arterial blood pressure glucose and insulin tolerance were evaluated after 8 weeks. Our results show that daily oral intake of the Asteraceae infused drink led to a reduction of body weight gain, hyperglycemia, hypertriglyceridemia, insulin resistance and hypertension. Moreover, rat-by-rat analysis of the insulinemia measures revealed two types of responders. One sub-group of subjects demonstrated normal insulinemia and the other subgroup demonstrated hyperinsulinemia. This hyperinsulinemia, associated with the inhibition of the glucose-6-phosphatase activity in the liver tissue, may suggest an insulin release caused by CGA. The present study suggests that this original infusion of dandelion leaves and burdock roots may be used as an adjuvant therapy to prevent metabolic syndrome.