Nanomedicine in glaucoma treatment; Current challenges and future perspectives

Glaucoma presents a significant global health concern and affects millions of individuals worldwide and predicted a high increase in prevalence of about 111 million by 2040. The current standard treatment involves hypotensive eye drops; however, challenges such as patient adherence and limited drug...

Full description

Saved in:
Bibliographic Details
Published in:Materials today bio 2024-10, Vol.28, p.101229, Article 101229
Main Authors: Iqbal, Haroon, Razzaq, Anam, Zhou, Dengming, Lou, Jiangtao, Xiao, Run, Lin, Fu, Liang, Yuanbo
Format: Article
Language:English
Subjects:
Eye drops
Glaucoma
Nanomedicine
Ocular drug delivery
Review
Sustained release
Targeted treatment
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glaucoma presents a significant global health concern and affects millions of individuals worldwide and predicted a high increase in prevalence of about 111 million by 2040. The current standard treatment involves hypotensive eye drops; however, challenges such as patient adherence and limited drug bioavailability hinder the treatment effectiveness. Nanopharmaceuticals or nanomedicines offer promising solutions to overcome these obstacles. In this manuscript, we summarized the current limitations of conventional antiglaucoma treatment, role of nanomedicine in glaucoma treatment, rational design, factors effecting the performance of nanomedicine and different types of nanocarriers in designing of nanomedicine along with their applications in glaucoma treatment from recent literature. Current clinical challenges that hinder real-time application of antiglaucoma nanomedicine are highlighted. Lastly, future directions are identified for improving the therapeutic potential and translation of antiglaucoma nanomedicine into clinic. Designing and development of nanomedicine using different nanocarriers for glaucoma treatment. [Display omitted]
ISSN:2590-0064
2590-0064
DOI:10.1016/j.mtbio.2024.101229