The diagnostic role of C2PAC index in cases of sepsis-induced coagulopathy (SIC)

Background To study the potential role of the C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) in sepsis-induced coagulopathy with the possibility of using this index as an early predictor in sepsis and sepsis-induced coagulopathy. Methods Our case–cont...

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Bibliographic Details
Published in:The Egyptian Journal of Bronchology 2023-12, Vol.17 (1), p.58-14, Article 58
Main Authors: Mousa, Mohamed Shaaban, Ahmed, Salwa Hassan, Maksoud, Fatma Abdel Wahab Abdel, Soliman, Soliman Belal, Tantawy, Ahmed A.
Format: Article
Language:English
Subjects:
Biomarkers
Blood platelets
Blood pressure
C lectin
C2PAC index
Coagulopathy
Critical Care Medicine
DIC
Endocarditis
Hypotension
Informed consent
Intensive
Lectins
Medicine
Medicine & Public Health
Pneumology/Respiratory System
Pneumonia
sCLEC-2
Sepsis
SIC
Thrombosis
Urinary tract infections
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Summary:Background To study the potential role of the C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) in sepsis-induced coagulopathy with the possibility of using this index as an early predictor in sepsis and sepsis-induced coagulopathy. Methods Our case–control study included a total of 86 participants divided into 2 groups: group I is the case group consisting of 56 patients of sepsis or septic shock and group II (control group) of 30 healthy persons: sex and age-matched healthy individuals. All patients were subjected to assessment of C lectin domain family 2 receptor (sCLEC2), by enzyme-linked immunosorbent assay ELIZA kit, then C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) was calculated using the platelet count. Results Our study demonstrated that sCLEC-2 levels and C2PAC in group I were higher than in group II ( p value 
ISSN:2314-8551
1687-8426
2314-8551
DOI:10.1186/s43168-023-00235-0