Polyacetylenes from the Roots of Swietenia macrophylla King

A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds ( - ) and two known ones ( - ). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for t...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-04, Vol.24 (7), p.1291
Main Authors: Mi, Cheng-Neng, Wang, Hao, Chen, Hui-Qin, Cai, Cai-Hong, Li, Shao-Peng, Mei, Wen-Li, Dai, Hao-Fu
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Carbon
Cell Line, Tumor
Cell Survival - drug effects
Chemical bonds
Cytotoxicity
Gastric cancer
Hepatocellular carcinoma
Humans
Inhibitory Concentration 50
K562 Cells
Leukemia
Meliaceae - chemistry
Molecular weight
Myeloid leukemia
Plant Roots - chemistry
Polyacetylene
Polyacetylene Polymer - chemistry
Polyacetylene Polymer - pharmacology
Roots
Swietenia macrophylla
Toxicity testing
Tumor cell lines
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Summary:A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds ( - ) and two known ones ( - ). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds and showed moderate cytotoxicity against the above three human cancer cell lines with IC values ranging from 14.3 to 45.4 μM. Compound displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC values of 26.2 ± 0.4 and 21.9 ± 0.3 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24071291