Association of interleukin-17F (rs763780) single nucleotide polymorphism with multiple sclerosis and optic neuritis

• Published in: Scientific reports 2024-06, Vol.14 (1), p.13643-8
• Main Authors: Salah, Shereen, Sadeq, Yousra I., Mosaad, Youssef M., Elmenshawi, Ibrahim E. H., Tawhid, Ziyad M. E.
• Format: Article
• Language: English
• Subjects: 631/208; 631/250; 631/337; 692/617; Adult; Alleles; Autoimmune diseases; Case-Control Studies; Egypt; Egyptian; Female; Gene Frequency; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotypes; Genotyping; Humanities and Social Sciences; Humans; IL-17F; Interleukin-17 - genetics; Male; Middle Aged; multidisciplinary; Multiple sclerosis; Multiple Sclerosis - genetics; Neuritis; Optic neuritis; Optic Neuritis - genetics; Polymorphism; Polymorphism, Single Nucleotide; Regression analysis; Risk factors; RT-PCR; Science; Science (multidisciplinary); Sex differences; Single-nucleotide polymorphism; SNP; Statistical analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-62736-2

IL-17F single nucleotide polymorphism (SNP) can affect IL-17F expression and activity and this can lead to the increased susceptibility to several autoimmune diseases. The aim was to investigate the association of IL-17F (rs763780) SNP with the development of multiple sclerosis (MS) in a cohort of Egyptian patients and to evaluate the effect of this polymorphism on the disease course. IL-17F (rs763780) gene polymorphisms was typed by TaqMan genotyping assay for 231 Egyptians divided into 102 MS patients and 129 healthy controls with matched age and sex. The IL-17F rs763780 C containing genotypes (CT+CC) and C allele have statistically significant increased frequency in MS patients when compared with controls ( p  = 0.005 and 0.004 respectively) especially in females’ patients ( p  = 0.005 and 0.006 respectively). The heterozygous CT genotype was associated with the presence of optic neuritis ( p  = 0.038). The multivariable regression analysis revealed significant associations between smoking, the higher frequency of attacks and the prediction of higher EDSS score ( p  = 0.032, 0.049 respectively). It can be concluded that the IL-17F rs763780 C containing genotypes (CT and CC) and C allele may be risk factors for the development of MS in the studied Egyptian cohort by a gender-dependent mechanism that contributes to tendency for predisposition in females and optic neuritis is more common in patients carrying the CT heterozygous genotype.