The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions : A Pilot Experiment

Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (...

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Bibliographic Details
Published in:Gastroenterology research and practice 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Sauer, Helene, Mack, Isabelle, Kohler, Silke, Siegle, Stefanie, Rieber, Nicole, Zipfel, Stephan, Otto, Bärbel, Ritze, Yvonne, Bischoff, Stephan C., Enck, Paul
Format: Article
Language:English
Subjects:
Enzymes
Fatty acids
Gastrointestinal system
Gene expression
Genetic aspects
Hormones
Irritable bowel syndrome
Medicine
Nervous system
Open access publishing
Plasma
Properties
Serotonin
Studies
Tryptamines
Weight control
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Summary:Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order. Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted. Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE. Results. GE was delayed with butter and was normal with olive (P
ISSN:1687-6121
1687-630X
DOI:10.1155/2014/424503