Antimutagenic effect of curcumin and its effect on the immune response in mice

A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micro...

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Bibliographic Details
Published in:Czech Journal of Food Sciences 2006-01, Vol.24 (2), p.72-83
Main Authors: Šmerák, Petr, Polívková, Zdeňka, Šestáková, Helena, Štětina, Rudolf, Bárta, Ivo, Langová, Martina, Turek, Bohumil, Bártová, Jiřina
Format: Article
Language:English
Subjects:
Aflatoxin B1
Aflatoxins
Ames test
antimutagenic effects
Bioassays
blastic transformation tests
Chemiluminescence
Comet assay
Curcumin
Diet
Genetic transformation
Immune response
Immune system
Immunomodulation
Immunosuppression
In vivo methods and tests
Inflammation
micronucleus test
Mutagenicity
Mutagens
Quinoline
response of immune
Toxicity
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Summary:A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.
ISSN:1212-1800
1805-9317
DOI:10.17221/3302-CJFS