Generalized pustular psoriasis (von Zumbusch)

Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt di...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2022-01, Vol.97 (1), p.63-74
Main Authors: Romiti, Ricardo, Hirayama, André Luís da Silva, Arnone, Marcelo, Magalhães, Renata Ferreira
Format: Article
Language:English
Subjects:
Acrodermatitis
Acute Disease
Chronic Disease
DERMATOLOGY
Exanthema
Humans
Psoriasis
Psoriasis - diagnosis
Psoriasis - drug therapy
Psoriasis/epidemiology
Psoriasis/genetics
Psoriasis/physiopathology
Psoriasis/therapy
Review
Skin Diseases, Vesiculobullous
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Description
Summary:Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1016/j.abd.2021.05.011