Prognostic significance of non-infarcted myocardium correlated with microvascular impairment evaluated dynamically by native T1 mapping

Objectives This study aimed to investigate the influence of microvascular impairment on myocardial characteristic alterations in remote myocardium at multiple time points, and its prognostic significance after acute ST-segment elevation myocardial infarction (STEMI). Methods Patients were enrolled p...

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Published in:Insights into imaging 2023-03, Vol.14 (1), p.50-50, Article 50
Main Authors: Chen, Bing-Hua, An, Dong-Aolei, Wu, Chong-Wen, Yue, Ting, Bautista, Matthew, Ouchi, Erika, Xu, Jian-Rong, Hu, Jiani, Zhou, Yan, Pu, Jun, Wu, Lian-Ming
Format: Article
Language:English
Subjects:
Diagnostic Radiology
Failure analysis
Fibrosis
Imaging
Impairment
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Mapping
Medicine
Medicine & Public Health
Myocardial infarction
Myocardium
Neuroradiology
Original
Original Article
Radiology
Regression analysis
T1 mapping
Ultrasound
Ventricular remodeling
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Summary:Objectives This study aimed to investigate the influence of microvascular impairment on myocardial characteristic alterations in remote myocardium at multiple time points, and its prognostic significance after acute ST-segment elevation myocardial infarction (STEMI). Methods Patients were enrolled prospectively and performed CMR at baseline, 30 days, and 6 months. The primary endpoint was major adverse cardiac events (MACE): death, myocardial reinfarction, malignant arrhythmia, and hospitalization for heart failure. Cox proportional hazards regression modeling was analyzed to estimate the correlation between T1 mapping of remote myocardium and MACE in patients with and without microvascular obstruction (MVO). Results A total of 135 patients (mean age 60.72 years; 12.70% female, median follow-up 510 days) were included, of whom 86 (63.70%) had MVO and 26 (19.26%) with MACE occurred in patients. Native T1 values of remote myocardium changed dynamically. At 1 week and 30 days, T1 values of remote myocardium in the group with MVO were higher than those without MVO ( p  = 0.030 and p  = 0.001, respectively). In multivariable cox regression analysis of 135 patients, native 1w T1 (HR 1.03, 95%CI 1.01–1.04, p  = 0.002), native 30D T1 (HR 1.05, 95%CI 1.03–1.07, p  
ISSN:1869-4101
1869-4101
DOI:10.1186/s13244-022-01360-y