Optimal single sampling time-point for monitoring of praziquantel exposure in children

Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate the optimal single sampling time-point for monitoring praziquantel exposure. This wa...

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Bibliographic Details
Published in:Scientific reports 2021-09, Vol.11 (1), p.17955-17955, Article 17955
Main Authors: Mnkugwe, Rajabu Hussein, Ngaimisi Kitabi, Eliford, Kinung’hi, Safari, Kamuhabwa, Appolinary A. R., Minzi, Omary Mashiku, Aklillu, Eleni
Format: Article
Language:English
Subjects:
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Children
Correlation coefficient
Enantiomers
Humanities and Social Sciences
Liquid chromatography
Medicin och hälsovetenskap
multidisciplinary
Pharmacokinetics
Plasma
Population studies
Praziquantel
Regression analysis
Sampling
Schistosomiasis
Science
Science (multidisciplinary)
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Summary:Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate the optimal single sampling time-point for monitoring praziquantel exposure. This was intensive pharmacokinetic study conducted among 32 Schistosoma mansoni infected children treated with an oral standard single-dose 40 mg/kg praziquantel. Plasma samples were collected at 0, 1, 2, 4, 6 and 8 h post-praziquantel administration. Quantification of praziquantel and its enantiomers ( R- and S- praziquantel) concentrations was done by Liquid chromatography-tandem mass spectrometer (LC–MS/MS). The correlation between area under the plasma concentration–time curve from 0 to 8 h (AUC 8 ) and plasma concentrations at each specific sampling time-point was determined by Pearson’s correlation coefficient (r 2 ). The median age (range) of the study population was 12.5 years (10–17). The study participants were 17 males and 15 females. Both total praziquantel and its enantiomers ( R- and S- praziquantel) displayed a wide inter-individual pharmacokinetic variability. Regression analysis indicated that, plasma concentrations collected at 4 h post-dose had a significantly highest correlation with the AUC 8 for both total praziquantel (r 2  = 0.81, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-97409-x