Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels

• Published in: Lipids in health and disease 2012-07, Vol.11 (1), p.50-50, Article 50
• Main Authors: Wu, Dong-Feng, Yin, Rui-Xing, Hu, Xi-Jiang, Aung, Lynn Htet Htet, Cao, Xiao-Li, Miao, Lin, Li, Qing, Yan, Ting-Ting, Wu, Jin-Zhen, Pan, Shang-Ling
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Asian Continental Ancestry Group - genetics; Base Sequence; Blood lipids; China; Electrophoresis, Agar Gel; Ethnic Groups - genetics; Female; Gene Frequency - genetics; Genes; Genetic aspects; Genetic Association Studies; Genetic research; Genotype; Genotyping Techniques; Humans; Lipids - blood; Low density lipoproteins; Male; Measurement; Middle Aged; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Scavenger Receptors, Class B - genetics; Sequence Analysis, DNA; Sex Characteristics; Single nucleotide polymorphisms; Young Adult
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/1476-511X-11-50

Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 (SCARB1) gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. A total of 598 subjects of Bai Ku Yao and 585 subjects of Han Chinese were randomly selected from our stratified randomized cluster samples. Genotypes of the SCARB1 rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) AI were lower but ApoB was higher in Bai Ku Yao than in Han (P