Antibiotic Resistance & Extended-Spectrum ß-Lactamase Production in Clinical and Non-Clinical Isolates in Tabuk

The increasing prevalence of antibiotic resistance, driven by the production of extended-spectrum beta-lactamases (ESBLs), presents a critical challenge to current medical treatments, particularly in clinical settings. Understanding the distribution and frequency of ESBL-producing bacteria is essent...

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Bibliographic Details
Published in:Medical sciences (Basel) 2024-09, Vol.12 (3), p.42
Main Authors: Alanazi, Badriah, Muhiuddin, Ghulam, Albalawi, Yazeed, Alhazmi, Khalid, Alzahrani, Othman, Alamri, Marai, Alshadfan, Hisham, Zubair, Mohammad
Format: Article
Language:English
Subjects:
Acids
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteria
Bacterial infections
Beta lactamases
Cephaloridine
Cephalosporins
clinical
CTX-M
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Bacterial
E coli
Enzymes
ESBL
Escherichia coli - drug effects
Food
Food Microbiology
Humans
Imipenem
Medical care, Cost of
Microbial Sensitivity Tests
Moxalactam
non-clinical
Pseudomonas - drug effects
Public health
SHV
TEM
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Summary:The increasing prevalence of antibiotic resistance, driven by the production of extended-spectrum beta-lactamases (ESBLs), presents a critical challenge to current medical treatments, particularly in clinical settings. Understanding the distribution and frequency of ESBL-producing bacteria is essential for developing effective control strategies. This study investigated the antibiotic resistance and extended-spectrum beta-lactamase (ESBL) production in bacterial isolates in clinical and non-clinical (food) specimens in Tabuk, KSA. A total of 57 bacterial isolates were analysed, with and sp. being the most prevalent. High resistance rates were observed, particularly against third-generation cephalosporins in clinical isolates. ESBL screening revealed a significant prevalence in clinical samples (58.3%), with showing the highest positivity. Conversely, only a low percentage of food isolates were ESBL positive. Molecular analysis confirmed the presence of various ESBL genes, with being the most frequent, predominantly found in clinical isolates. This study highlights the concerning levels of antibiotic resistance and ESBL production in the region, emphasising the need for effective infection control measures and prudent antibiotic use.
ISSN:2076-3271
2076-3271
DOI:10.3390/medsci12030042