Differential expression of long non-coding RNA Regulator of reprogramming and its molecular mechanisms in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproductive age. Multiple studies have shown that long non-coding RNAs (lncRNA) and microRNAs (miRNA) play a role in PCOS. This study aimed to explore the role and molecular mechanism of lncRNA -Regulator of reprogramming (l...

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Bibliographic Details
Published in:Journal of ovarian research 2021-06, Vol.14 (1), p.79-79, Article 79
Main Authors: Zhang, Zhihong, Sang, Min, Liu, Siqin, Shao, Jing, Cai, Yunjiang
Format: Article
Language:English
Subjects:
Adult
Analysis
Angiogenesis
Apoptosis
Cell culture
Cell division
Cell Proliferation
Cholecystokinin
Disease
Down-regulation
Endocrine disorders
Endometrium
Female
Genetic research
Humans
Hyperplasia
Metabolic disorders
MicroRNA
MiR-206
miRNA
Molecular modelling
Non-coding RNA
Ovarian cancer
Ovulation
Plasmids
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Polycystic Ovary Syndrome - pathology
Regulator of reprogramming
Reporter gene
RNA, Long Noncoding - metabolism
Statistical analysis
Stein-Leventhal syndrome
Stem cells
Transfection
Type 2 diabetes
Vascular endothelial growth factor
Womens health
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Summary:Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproductive age. Multiple studies have shown that long non-coding RNAs (lncRNA) and microRNAs (miRNA) play a role in PCOS. This study aimed to explore the role and molecular mechanism of lncRNA -Regulator of reprogramming (lncROR) in PCOS. Expression level of lncROR in PCOS patients was up-regulated, while level of miR-206 was down-regulated in comparison with control group (P 
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-021-00829-6