Differential expression of long non-coding RNA Regulator of reprogramming and its molecular mechanisms in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproductive age. Multiple studies have shown that long non-coding RNAs (lncRNA) and microRNAs (miRNA) play a role in PCOS. This study aimed to explore the role and molecular mechanism of lncRNA -Regulator of reprogramming (l...

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Published in:Journal of ovarian research 2021-06, Vol.14 (1), p.79-79, Article 79
Main Authors: Zhang, Zhihong, Sang, Min, Liu, Siqin, Shao, Jing, Cai, Yunjiang
Format: Article
Language:English
Subjects:
Adult
Analysis
Angiogenesis
Apoptosis
Cell culture
Cell division
Cell Proliferation
Cholecystokinin
Disease
Down-regulation
Endocrine disorders
Endometrium
Female
Genetic research
Humans
Hyperplasia
Metabolic disorders
MicroRNA
MiR-206
miRNA
Molecular modelling
Non-coding RNA
Ovarian cancer
Ovulation
Plasmids
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Polycystic Ovary Syndrome - pathology
Regulator of reprogramming
Reporter gene
RNA, Long Noncoding - metabolism
Statistical analysis
Stein-Leventhal syndrome
Stem cells
Transfection
Type 2 diabetes
Vascular endothelial growth factor
Womens health
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creator Zhang, Zhihong
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description Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproductive age. Multiple studies have shown that long non-coding RNAs (lncRNA) and microRNAs (miRNA) play a role in PCOS. This study aimed to explore the role and molecular mechanism of lncRNA -Regulator of reprogramming (lncROR) in PCOS. Expression level of lncROR in PCOS patients was up-regulated, while level of miR-206 was down-regulated in comparison with control group (P 
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Multiple studies have shown that long non-coding RNAs (lncRNA) and microRNAs (miRNA) play a role in PCOS. This study aimed to explore the role and molecular mechanism of lncRNA -Regulator of reprogramming (lncROR) in PCOS. Expression level of lncROR in PCOS patients was up-regulated, while level of miR-206 was down-regulated in comparison with control group (P &lt; 0.001). Logistics regression analysis showed that lncROR and miR-206 were independent predictors of PCOS. The ROC curve showed that lncROR had a high diagnostic value for PCOS with an AUC value of 0.893. Pearson correlation coefficient indicated that the expression level of miR-206 was negatively correlated with the level of lncROR. CCK-8 assay and apoptosis assay revealed that downregulation of lncROR up-regulated the expression of miR-206, thereby inhibiting cell proliferation and promoting cell apoptosis. However, silencing the expression of miR-206 reversed the above effects caused by down-regulation of lncROR expression. Luciferase reporter gene assay suggested that there was a target relationship between lncROR and miR-206. VEGF was proved to be the target gene of miR-206. 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However, silencing the expression of miR-206 reversed the above effects caused by down-regulation of lncROR expression. Luciferase reporter gene assay suggested that there was a target relationship between lncROR and miR-206. VEGF was proved to be the target gene of miR-206. Highly expressed lncROR indirectly up-regulated the expression of VEGF by down-regulating the expression of miR-206, thereby promoting the proliferation of KGN cells and inhibiting apoptosis, and further promoting the development of PCOS.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>34148561</pmid><doi>10.1186/s13048-021-00829-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Analysis
Angiogenesis
Apoptosis
Cell culture
Cell division
Cell Proliferation
Cholecystokinin
Disease
Down-regulation
Endocrine disorders
Endometrium
Female
Genetic research
Humans
Hyperplasia
Metabolic disorders
MicroRNA
MiR-206
miRNA
Molecular modelling
Non-coding RNA
Ovarian cancer
Ovulation
Plasmids
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Polycystic Ovary Syndrome - pathology
Regulator of reprogramming
Reporter gene
RNA, Long Noncoding - metabolism
Statistical analysis
Stein-Leventhal syndrome
Stem cells
Transfection
Type 2 diabetes
Vascular endothelial growth factor
Womens health
title Differential expression of long non-coding RNA Regulator of reprogramming and its molecular mechanisms in polycystic ovary syndrome
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