The Role of Proteases in the Virulence of Plant Pathogenic Bacteria

A pathogenic lifestyle is inextricably linked with the constant necessity of facing various challenges exerted by the external environment (both within and outside the host). To successfully colonize the host and establish infection, pathogens have evolved sophisticated systems to combat the host de...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-02, Vol.20 (3), p.672
Main Authors: Figaj, Donata, Ambroziak, Patrycja, Przepiora, Tomasz, Skorko-Glonek, Joanna
Format: Article
Language:English
Subjects:
Amino acids
Bacteria
bacterial virulence
Barriers
Binding sites
Biodegradation
Colonization
Crystal structure
effector proteases
Environmental conditions
Enzymes
extracellular proteases
Infections
Microorganisms
Pathogens
Peptides
plant pathogenic bacteria
Proteins
Proteolysis
Proteolytic enzymes
Quality control
regulatory proteolysis
Review
Roles
Substrate specificity
T3SS
Virulence
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Summary:A pathogenic lifestyle is inextricably linked with the constant necessity of facing various challenges exerted by the external environment (both within and outside the host). To successfully colonize the host and establish infection, pathogens have evolved sophisticated systems to combat the host defense mechanisms and also to be able to withstand adverse environmental conditions. Proteases, as crucial components of these systems, are involved in a variety of processes associated with infection. In phytopathogenic bacteria, they play important regulatory roles and modulate the expression and functioning of various virulence factors. Secretory proteases directly help avoid recognition by the plant immune systems, and contribute to the deactivation of the defense response pathways. Finally, proteases are important components of protein quality control systems, and thus enable maintaining homeostasis in stressed bacterial cells. In this review, we discuss the known protease functions and protease-regulated signaling processes associated with virulence of plant pathogenic bacteria.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20030672