Cenostigma macrophyllum Tul. on the healing of skin wounds in rats with Diabetes mellitus

PURPOSE: To investigate the effect of Cenostigma macrophyllum Tul. in the tissue repair process of skin lesions in rats with induced Diabetes mellitus. METHODS: Sixty-three male Wistar rats were distributed into three groups: control (C), diabetic (D), and diabetic treated with an oil-in-water emuls...

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Published in:Acta cirúrgica brasileira 2013-08, Vol.28 (8), p.594-600
Main Authors: Coelho, Nayana Pinheiro Machado de Freitas, Nogueira, Veruska Cronemberger, Cardoso, Maria Angélica Gargione, Lopes, Luciano da Silva, Nascimento, Paulo Pedro do, Rocha, Evair dos Santos, Silva, Caio Leôncio Probo da, Arisawa, Emília Ângela Loschiavo
Format: Article
Language:English
Subjects:
Diabetes mellitus
Nitric Oxide
Plants, Medicinal
Rats
Skin
Wound Healing
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Summary:PURPOSE: To investigate the effect of Cenostigma macrophyllum Tul. in the tissue repair process of skin lesions in rats with induced Diabetes mellitus. METHODS: Sixty-three male Wistar rats were distributed into three groups: control (C), diabetic (D), and diabetic treated with an oil-in-water emulsion of the plant (DPL) subdivided according to time of observation (seven, 14, and 28 days). Diabetes was induced by administration of by injection of streptozotocin (50 mg/kg, after a 12-h fast) into the penile vein and confirmed by glucose levels exceeding 240 mg/dL. Held surgical lesion (2.5 cm in diameter) on the back of the animals. The DPL received topical application of group of the oil-in-water emulsion plant (0.5ml). To evaluate the levels of nitric oxide, was collected 5ml of blood from the abdominal aorta, after his euthanasia. The samples of interest were sent for routine histological processing. RESULTS:A reduction in the percentage of inflammatory cells and increased numbers of fibroblasts in the group DPL, seven days, compared to the other groups. At 14 days, the DPL group also showed a higher concentration of nitric oxide (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502013000800007