Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice

Schistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection wit...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 1987, Vol.82 Suppl 4 (suppl 4), p.283-284
Main Authors: Horta, M F, Ramalho-Pinto, F J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - biosynthesis
Antibodies, Helminth - immunology
Immune Tolerance
Immunoglobulin G - biosynthesis
Immunoglobulin G - immunology
Larva
Mice
PARASITOLOGY
Rats
Schistosoma mansoni - growth & development
Schistosoma mansoni - immunology
Schistosomiasis mansoni - immunology
TROPICAL MEDICINE
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Summary:Schistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection with a peak in the 6-8th week of infection. This activity declined to non-detectable levels within 2 weeks, remaining low up to the 20-26th week. In mice, lethal antibody was not detected before 7-12 weeks of infection, but raised to higher levels, as compared to non-infected animals, up to 20-24 weeks after infection. We correlate lethal antibody and protective immunity suggesting that the antibody-mediated complement-dependent cytotoxicity to schistosomula play a role in the immunity to reinfection.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/S0074-02761987000800053