Hematologic Profiles and Correlation Between Absolute Lymphocyte Count and Neutrophil/Lymphocyte Ratio with Markers of Inflammation of COVID-19 in an Indonesian National Referral Hospital

COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.6919-6924
Main Authors: Sukrisman, Lugyanti, Sinto, Robert, Priantono, Dimas
Format: Article
Language:English
Subjects:
Analysis
Blood
C-reactive protein
Coronaviruses
COVID-19
Dehydrogenases
Disease
Epidemics
Ferritin
Health aspects
hematologic profiles
Hematology
Hemoglobin
Hospitalization
Hospitals
Indonesia
Infections
Inflammation
Laboratories
lymphocyte
Lymphocytes
Medical research
Medicine, Experimental
Mortality
Neutrophils
nlr
Normal distribution
Original Research
Patients
Pneumonia
Proteins
Severe acute respiratory syndrome coronavirus 2
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Summary:COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity. A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Cipto Mangunkusumo Hospital. Lymphocyte count, NLR, C-reactive protein (CRP) and ferritin were evaluated in severe and non-severe COVID-19 cases at hospital admission. Data was analyzed using Spearman correlation. There were 41 patients aged 20 to 79 years with COVID-19; 33 (80.5%) were non-severe, and 8 (19.5%) were severe cases. There is a statistically significant difference in WBC, relative neutrophils and lymphocytes, NLR, and CRP between non-severe and severe cases. There is a strong correlation between NLR and CRP (r = 0.738; p < 0.001). Our findings show that NLR and absolute lymphocyte count, but not ferritin, play a role in differentiating between non-severe and severe COVID-19 cases. In COVID-19 cases, a strong correlation between NLR and CRP might suggest the use of NLR to differentiate between non-severe and severe cases, especially in a remote healthcare facility.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S337440