Comparison of the Clinical Characteristics and Severity of Influenza and Non-influenza Respiratory Virus-Related Pneumonia in China: A Multicenter, Real-World Study

• Published in: Infection and drug resistance 2020-01, Vol.13, p.3513-3523
• Main Authors: Chen, Liang, Han, Xiu-Di, Li, Yan-Li, Zhang, Chun-Xiao, Xing, Xi-Qian
• Format: Article
• Language: English
• Subjects: Adenoviruses; Age; Cardiovascular disease; Cerebrovascular disease; China; clinical characteristics; Comparative analysis; Coronaviruses; Data collection; Development and progression; Hospital patients; Hospitalization; Influenza; Influenza A; Influenza B; Laboratories; Lung diseases; Lymphocytes; Mortality; Myalgia; Normal distribution; Original Research; Pathogens; Patients; Pneumonia; Regression analysis; Respiratory syncytial virus; respiratory virus; severity; Streptococcus infections; Ventilators; Viral infections; Viruses
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S267102

Respiratory viruses are important etiologies of community-acquired pneumonia (CAP). However, the impact of different RVs on the outcomes of CAP is not well elucidated. This study aims to compare the clinical features and severity of influenza (Flu-p) and non-influenza respiratory viruses-related pneumonia (NIRVs-p) onset in the community among immunocompetent adults. The data of the patients hospitalized with laboratory-confirmed RVs-p were retrospectively reviewed from five teaching hospitals in China from January 2013 to May 2019. Univariate and multivariate logistic regressions were performed to compare the clinical characteristics and outcomes between Flu-p and NIRVs-p. A total of 1079 patients with Flu-p and 341 patients with NIRVs-p were included in this study. A multivariate logistic regression model revealed chronic pulmonary disease [odd ratio (OR) 0.341, 95% confidence interval (CI) 0.225-0.515, < 0.001], solid malignant tumor (OR 0.330, 95% CI 0.163-0.668, = 0.002), myalgia (OR 1.697, 95% CI 1.236-2.330, < 0.001), lymphocytes