Evaluation of Specificity and Sensitivity of Oral Fluid for Diagnosis of Hepatitis B

Hepatitis B viral infection is a global health issue. Various screening and confirmatory serological tests have evolved in the past few decades for detection of hepatitis B. However, oral fluid as an alternative to blood could provide substantial advantages. The study aimed to evaluate the diagnosti...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2016-01, Vol.10 (1), p.BC12-BC14
Main Authors: Khadse, Smita V, Bajaj, Gunjan, Vibhakar, Pavitra, Nainani, Purshotam, Ahuja, Rinky, Deep, Gagan
Format: Article
Language:English
Subjects:
Biochemistry Section
elisa
non-invasive
saliva
viral hepatitis
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Summary:Hepatitis B viral infection is a global health issue. Various screening and confirmatory serological tests have evolved in the past few decades for detection of hepatitis B. However, oral fluid as an alternative to blood could provide substantial advantages. The study aimed to evaluate the diagnostic efficacy of oral fluid in detecting hepatitis B surface antigen using Enzyme Linked Immunosorbent Assay (ELISA). Salivary and blood samples were collected from 40 seropositive and 40 seronegative patients of hepatitis B viral infection and were subjected to ELISA test for hepatitis B surface antigen. Mann-Whitney U test was used to test the statistical significance and Kappa (K) statistic was used to assess the degree of agreement between serum and oral fluid samples. The p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/17319.7107